| Objective:To analyze the levels of serum vitamin A and D in children with respiratory tract infection,and to investigate the correlation between respiratory tract infection and serum vitamin A and D.Methods:Three hundred and sixty-four children from February 2019 to January 2020 were extracted to be divided into the recurrent respiratory tract infection in acute infection(RRI in acute),recurrent respiratory tract infection in non-acute infection(RRI in non-acute),acute respiratory tract infection(acute infection)and control group(healthy children during the same period).Acute respiratory tract infection include acute upper respiratory infection,acute bronchitis and pneumonia.The serum vitamin A and D levels were measured by liquid chromatography tandem-mass spectrometry(LC-MS /MS).Analysis :(1)general data of children of the four groups.(2)serum vitamin A and D levels of the four groups.(3)serum vitamin A and D levels of severe pneumonia group and general pneumonia group(Children with pneumonia were divided into severe pneumonia group and general pneumonia group according to the severity of their conditions).(4)serum levels of vitamin A and D in children of different age groups.(The three hundred and sixty-four children were divided into <3 years old group and >3 years old group by age.)Results:1.There was no significant difference in general data of the four groups(P>0.05).2.The distribution of serum vitamin A levels in the four groups were skewed distribution,and the difference was statistically significant(P<0.05).3.In the four groups,total detection rate of serum vitamin A level≤0.3mg/L was 55.8%,and≤0.2mg/L was 20.3%.There was a statistically significant difference in the detection rates of sub-clinical vitamin A deficiency(SVAD)(P<0.05);Multiple comparison between multi-sample rates,according to the test level of α’= 0.0083: the detection rates of SVAD in the recurrent respiratory tract infection in acute infection group(32.9%)and acute respiratory tract infection group(26.3%),were significantly higher than control group(4.9%),and the difference were statistically significant(P<0.0083);there was no statistically significant difference between the rest of two pairings(P>0.0083).The detection rates of marginal vitamin A deficiency(MVAD)in the four groups was no statistically significant difference(P>0.05).4.The serum vitamin D levels of recurrent respiratory tract infection in acute infection,recurrent respiratory tract infection in non-acute infection,acute respiratory tract infection and control groups were(17.54±6.00)ng/mL,(24.61±9.28)ng/mL,(25.73±10.01)ng/mL,(30.11±10.39)ng/mL;the difference was statistically significant(P<0.05).Comparison of serum vitamin D levels in pairs of the four groups: the serum vitamin D levels of the three case groups were all significantly lower than control group,and the difference were all statistically significant(P<0.05);the serum vitamin D level of recurrent respiratory tract infection in acute infection group was significantly lower than the others,and the differences were all statistically significant(P<0.05);there was no significant difference between the recurrent respiratory tract infection in non-acute infection and acute respiratory tract infection group(P>0.05).5.In the four groups,total detection rate of serum vitamin D level≤20ng/mL was 34.9%.And there was a statistically significant difference in the detection rates of vitamin D deficiency of the four groups(P<0.05);multiple comparison between multisample rates,according to the test level of α’= 0.0083: only the recurrent respiratory tract infection in acute infection group was significantly higher than the control group in the detection rates of vitamin D deficiency,and the difference was statistically significant(P<0.0083).Moreover,there also was a statistically significant difference in the detection rates of vitamin D insufficiency of the four groups(P<0.05);Multiple comparison between multi-sample rates,according to the test level of α’= 0.0083: the detection rate of recurrent respiratory tract infection in acute infection group was significantly higher than the others three groups,and the differences were all statistically significant(P<0.0083);acute respiratory tract infection was significantly higher than the control group,and the difference was statistically significant(P<0.0083);there was no statistically significant difference between the rest of two pairings(P>0.0083).6.The serum vitamin A level of severe pneumonia group was(0.19±0.05)mg/L,general pneumonia group was(0.27±0.08)mg/L,and the difference was statistically significant(P<0.05).There was no statistically significant difference in serum vitamin D levels between the two groups.7.The serum vitamin A levels in different age groups was no statistically significant difference(P>0.05).The serum vitamin D level of <3 years old group was(31.47±11.31)ng/mL,>3 years old group was(22.75±8.75)ng/mL,and the difference was statistically significant(P<0.05).The detection rates of vitamin D deficiency and vitamin D insufficiency in>3 years old group was significantly higher than the <3 years old group,and the difference was statistically significant(P<0.05).Conclusion:1.Respiratory tract infection is closely related to serum levels of vitamin A and D in children:(1)The severity of infection and current illness or no is related to serum levels of vitamin A;(2)The frequency of infection and current illness or no is related to serum levels of vitamin D levels.2.In Yan’an prefecture,vitamin A nutrition of children is not optimistic and the lack of vitamin D is more common in older children. |
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