| ObjectiveIn this study,through the clinical observation of the treatment of cirrhosis with qi stagnation and dampness-blocking cirrhosis ascites by Xingqi Huashi Lishui Prescription,he comprehensive clinical efficacy and drug safety were evaluated,and the advantages of TCM syndrome differentiation were discussed,so as to provide an effective treatment scheme for the clinical treatment of cirrhosis with qi stagnation and dampness obstruction.Methods72 patients meeting the diagnostic criteria who were admitted to the liver disease outpatient or inpatient department of hospital from June 2019 to June 2020 were selected and randomly divided into the treatment group and the control group,with 36 cases in each group.After inclusion,patients in the control group were treated with cirrhosis ascites,and patients in the treatment group were additively treated with Xingqi Huashi Lishui Decoction.The two groups were treated for 12 weeks and followed up for 3 months to evaluate the comprehensive efficacy.The changes of clinical symptoms,liver and kidney function,ascites subsidence,recurrence rate,comprehensive efficacy and drug safety in 2 groups were observed.SPSS25.0 statistical software was used for statistical analysis.Results1.During the treatment process,1 patient in the treatment group and 1 patient in the control group withdrew from treatment due to personal reasons,so there were 35 patients in the treatment group and 35 patients in the control group,and a total of 70 patients completed this study.2.Analysis of clinical integration efficacy:after treatment,6 cases of complete remission,15 cases of obvious effect,12 cases of effective effect and 2 cases of ineffective effect were found in the treatment group;In the control group,there were 3 cases of complete remission,7 cases of obvious effect,17 cases of effective and 8 cases of ineffective.The effective rate of the treatment group was 94.28%,which was significantly higher than that of the control group(77.14%),and there was significant difference in the comprehensive efficacy between the two groups(P<0.05).3.TCM syndrome score and efficacy evaluation analysis:the total syndrome score in both groups decreased significantly after treatment(P<0.01),and the decrease was more significant in the treatment group(P<0.01).In terms of the curative effect of TCM syndromes,there were 32 effective patients and 3 ineffective patients in the treatment group.In the control group,there were 25 effective patients and 10 ineffective patients.The effective rate of the control group(91.43%),which was significantly higher than that of the treatment group(71.43%),and there was a significant difference between the two groups in judging the efficacy of TCM(P<0.05).4.Analysis of liver function treatment:after treatment,ALT,AST and TB in 2 groups were significantly decreased(P<0.01),and ALB was significantly increased(P<0.01).Compared with the control group,ALT,AST and TB in the treatment group were more significantly decreased(P<0.05,P<0.01,P<0.05),and ALB was more significantly increased(P<0.05).5.Renal function analysis:after treatment,Cr and BUN in 2 groups were significantly decreased(P<0.01),compared with the control group,the decrease of Cr and BUN in the treatment group was more obvious(P<0.05).6.Analysis of curative effect of ascites:after treatment,ascites depth,24h urine volume,abdominal circumference and weight in 2 groups were improved compared with before(P<0.01);24h urine volume,ascites depth,abdominal circumference and weight in treatment group were better than those in control group(P<0.01,P<0.05).After treatment,the values of abdominal moisture in both groups were improved,and the improvement in the treatment group was better than that in the control group(P<0.05).7.Analysis of spleen thickness after treatment:After treatment,spleen thickness in both groups decreased compared with before(P<0.01),but there was no significant difference between the treatment group and the control group(P>0.05).8.Analysis of the recurrence rate:After the treatment,the effective patients were followed up for 3 months.In the first month,the recurrence rate of the treatment group was 6.0%,and the recurrence rate of the treatment group was 22.2%.There was no significant difference between the two groups(P>0.05).At the 3rd month,the recurrence rate of the treatment group was 9.0%,and that of the control group was 33.3%.There was a significant difference between the two groups(P<0.05).9.Drug safety analysis:No adverse reactions occurred in patients of the two groups during the treatment,and no obvious abnormalities were found in safety indicators,indicating that the formula used in this study was safe and reliable without obvious toxic and side effects.Conclusion1.Applying Qi Shi Li Shui Formula can effectively subside ascites,improve the clinical symptoms and liver and kidney functions of patients,stabilize the condition and reduce the recurrence rate,with significant therapeutic effect.2.During the treatment,there was no significant abnormality in the safety indicators of patients in the two groups,suggesting that the treatment of gasification and moistening water is safe and effective without obvious toxic and side effects. |
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