Clinical Observation On The Treatment Of Spleen-deficiency Dampness Stagnation Type 1 Cervical Intraepithelial Neoplasia With Cervical High-risk Human Papillomavirus Infection With Jianpi Huashi Decoction

Objective : To observe the clinical effect of Jianpi Huashi prescription on cervical intraepithelial neoplastia 1(CIN1)with high risk human papillomavirus(HR-HPV)infection,and explore the effective Chinese medicine in the treatment of cervical lesions and prevent the occurrence of cervical cancer.Methods: This clinical observation was divided into two groups,the experimental group and the control group.A total of 80 cases of cin1 patients with HR-HPV infection of spleen deficiency and dampness stagnation syndrome were randomly divided into two groups,40 cases in each group.Experimental group: Jianpi Huashi prescription combined with interferon vaginal effervescent tablets,Jianpi Huashi prescription was taken in premenstrual period,one dose per day,10 days as a course of treatment,6 courses of treatment;Interferon was administered intravaginally three days after menstruation,once every other day,500000 IU each time,nine times a month as a course of treatment,and stopped after three courses of treatment.The control group was treated with interferon vaginal effervescent tablets,and the usage was the same as that of the experimental group.Each group was selected into the group in the month after the diagnosis was clear,and the treatment was started according to each group plan after the menstruation was clean.The month of treatment was defined as the first month.After the menstruation was clean in the seventh month,the liquid based cytology(TCT)and HR-HPV were reexamined,and the TCM syndrome score was performed again.Finally,the results were statistically analyzed.Results:(1)A total of 80 patients were included,including 3 cases of shedding,38 cases in the experimental group and 39 cases in the control group.(2)The negative rate of cervical high-risk HPV: the experimental group: 86.84%,the control group: 61.53%,the difference was statistically significant(P < 0.05).There was no significant difference in the negative conversion rate of three kinds of infection in the experimental group(P > 0.05).In the control group,the three types of infection rates were compared in pairs,only the other 12 high-risk infection rates and mixed infection rates were compared,the difference was statistically significant(P< 0.017).There was no significant difference in the negative conversion rate between the experimental group and the control group(P > 0.05).There was a significant difference in the negative conversion rate between the experimental group and the control group(P < 0.05).(3)Cin1 reversal rate: the cin1 reversal rates of the experimental group and the control group were 89.5% and 56.41% respectively,and the difference between the two groups was statistically significant(P< 0.05).(4)TCM curative effect: after treatment,the symptom scores of spleen deficiency and dampness stagnation of the two groups were reduced,and the score reduction of the experimental group was higher than that of the control group,with statistical significance(P < 0.05).(5)Comprehensive efficacy evaluation: the clinical effective rates of the experimental group and the control group were 92.11% and 66.67% respectively,and the difference was statistically significant(P < 0.05).Conclusion: Jianpi Huashi prescription Combined with interferon in the treatment of cervical intraepithelial neoplasia grade 1 with cervical high-risk HPV infection of spleen deficiency and dampness stagnation type can effectively improve the cin1 reversal rate,the total clearance rate of HPV infection and the clearance rate of mixed infection,improve the clinical symptoms of traditional Chinese medicine and significantly improve the clinical comprehensive efficacy.However,there was no significant difference in the clearance rate of HPV infection between 16 / 18 and other12 high-risk HPV types.