| Objective:To observe the clinical efficacy of modified Guizhi Mahuang Geban Decoction in the treatment of urticaria with pattern of wind-cold attack and its effect on serum total IgE and serum IL-6 levels.Methods:70 patients with urticaria with pattern of wind-cold attack who visited the outpatient department of dermatology,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from March 2019 to March 2020 were randomly divided into treatment group and control group,with 35 patients in each group.The treatment group took modified Guizhi Mahuang Geban Decoction while the control group took loratadine tablets orally for 4 weeks.During treatment,No other therapies should be used.The patient’s condition was evaluated before and after treatment.Urticaria symptoms and signs score,Dermatology Life Quality Index(DLQI)score,adverse reaction rate,recurrence rate,serum immunoglobulin E(Immunoglobulin E,IgE),interleukin-6(Interleuki,IL-6)levels and other indicators were used to evaluate clinical efficacy and explore its mechanism of action.Results:(1)Seventy patients were included in this study.Finally,68 patients completed the study,2 patients belonging to the control group and the treatment group shedding,with 34 cases in the treatment group and the control group.(2)There was no statistically significant difference in gender,age,course of disease,symptom and sign score,DLQI score,DLQI severity distribution,and serum IgE level between the two groups before treatment(P>0.05).(3)After treatments,the differences in the symptoms and signs of the two groups and the total score were compared.The degree of pruritus,the duration of wind mass,frequency of attacks and the total score were lower than before(P<0.05),and the treatment group was better than the control group(P<0.05).However,the number of wind masses and the maximum diameter of wind masses were not significantly different between the two groups after treatment(P>0.05).The symptoms and signs scores of the treatment group and the control group were compared respectively.There were differences between the two groups of scores before and after treatment,and the treatment of the two groups was effective(P>0.05).(4)The average DLQI score of the treatment group before treatment was(14.91±5.95)points,after treatment it was(2.06 ± 2.99)points.The average DLQI score of the control group was(14.74±5.50)points,and it was(4.70±5.3.85)points.The difference in DLQI scores between the two groups of cases before and after treatment was statistically significant(P<0.05).After different treatments,there were differences in DLQI scores between the treatment group and the control group(P<0.05).And the DLQI score of the treatment group after treatment was significantly lower than that of the control group.(5)The difference in the distribution of DLQI scores was statistically significant before and after treatment between the treatment group and the control group(P<0.05).70.3% of the patients in the treatment group had no impact on the severity of the DLQI score,compared with 41.2% in the control group after treatment.(6)There was no difference in serum total IgE levels between the two groups before and after treatment(P>0.05),and there was no significant difference in serum total IgE between the treatment group and the control group after treatment(P<0.05).(7)Serum IL-6 levels after treatment in the treatment group and the control group were lower than before treatment(P<0.05).After treatment,the serum IL-6 level of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).(8)The effective rate of the treatment group was 88.23%,and the effective rate of the control group was 76.47%.The clinical efficacy of the treatment group was higher than that of the control group(P<0.05).During the course of treatment,neither group of patients had serious adverse reactions or allergies.(9)6 months after the end of treatment,the patients in the two groups who were treated effectively were followed up.The recurrence rate of the two groups was compared by re-scoring the clinical symptoms.The relapse rate of the treatment group was lower than that of the control group(P<0.05).Conclusion:(1)Modified Guizhi Mahuang Geban Decoction had significant clinical effect in treating urticaria with pattern of wind-cold attack,which can effectively relieve clinical symptoms and improve the quality of life of patients.(2)Modified Guizhi Mahuang Geban Decoction for the treatment of urticaria with pattern of wind-cold attack may be achieved by reducing the serum IL-6 level and the specific mechanism remains to be further studied.(3)Modified Guizhi Mahuang Geban Decoction can reduce the recurrence rate of urticaria with pattern of wind-cold attack. |
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