Clinical Observation Of Chaihu Plus Longgumuli Decoction In Treating Gastroesophageal Reflux Disease With Stagnation Of Liver And Stomach

Objective: By observing the improvement of the clinical efficacy of Chaihu plus Longgumuli Decoction in the treatment of patients with gastroesophageal reflux disease with stagnation of liver and stomach heat and its impact on the quality of life,including the scores on reflux disease questionnaires,TCM syndrome scores,quality of life scores and relapse Rate indicators are evaluated,aiming to provide data support for the efficacy and safety of Chaihu plus Longgumuli Decoction in the treatment of gastroesophageal reflux disease with stagnant heat of the liver and stomach.Methods: This study selected 60 subjects who were hospitalized in the Gastroenterology Department of Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine from January 2019 to September2020 and were diagnosed with gastroesophageal reflux disease and the TCM syndrome type was liver and stomach stagnant heat.Numbered according to the time of visit,and divided into treatment group and control group with 30 cases each by random number method.The treatment group was given the traditional Chinese medicine decoction Chaihu plus Longgumuli Decoction,and the control group was given pantoprazole sodium enteric-coated tablets.The treatment course of the two groups was 8 weeks.Observe and record the reflux disease questionnaire(RDQ)scores,TCM symptom scores,quality of life scores and the improvement of the recurrence rate of the two groups of patients before and after treatment.At the same time,the adverse reactions of the two groups of patients during the test period were monitored and recorded.The statistical software SPSS25.0 was used to perform statistical analysis on the clinical collected data.Results:1.Comparison of the curative effect of western medicine clinical symptoms of the two groups of patients: 7 people in the treatment group recovered,9people were effective,12 people were effective,and 2 people were ineffective.The overall effective rate was 93.33%;in the control group,3 people were cured,5 people were markedly effective,and 17 people were effective.5people were ineffective,and the overall effective rate was 83.33%;the clinical efficacy of western medicine in the treatment group was better than that in the control group(P<0.05).2.Comparison of the RDQ scores of the two groups of patients: After treatment,the RDQ scores of the two groups of patients can be effectively reduced(P<0.05),and the comparison between the groups indicates that the improvement of the treatment group is better than that of the control group(P<0.05).3.Comparison of TCM syndrome scores:(1)In terms of main symptoms(heartburn,acid reflux),the treatment group is better than the control group(P<0.05);(2)Minor symptoms(upset,irritability,sigh,stomach noisy,easy hunger,uncomfortable stool,belching)In terms of efficacy,the two groups of patients had the same curative effect(P>0.05);but in terms of improving dry mouth and bitterness,the treatment group had better improvement than the control group(P<0.05).4.Comparison of quality of life scores: After treatment,the quality of life scores of the two groups of patients were higher than those before treatment(P<0.05),and the treatment group was better than the control group(P<0.05).5.Comparison of recurrence rate: 4 weeks after the treatment,the groups who were excluded from the treatment group were followed up.Of the 28 cases in the treatment group,3 cases relapsed,with a recurrence rate of 10.7%;in the control group,7 cases relapsed,with a recurrence rate.30.4%,the difference was statistically significant(P<0.05),indicating that the short-term recurrence rate of the treatment group was lower than that of the control group.6.Safety analysis: There were no serious adverse reactions during the treatment of the two groups of patients.Conclusion(s):For patients with gastroesophageal reflux disease due to stagnation of liver and stomach heat,the use of Chaihu plus Longgumuli Decoction can effectively improve their clinical symptoms,reduce recurrence,and improve their quality of life.It is worthy of clinical application.