| OBJECTIVE:This study aims to evaluate the effects of Jianpi Huayu Prescription on tissue factor-mediated advanced gastric cancer by observing the changes in blood coagulation indexes,tissue factors,inflammatory factors,TCM syndrome integration,and platelet aggregation function in patients after oral administration of Jianpi Huayu Prescription The influence of the patient’s hypercoagulable state provides a certain scientific basis for the prevention and treatment of hypercoagulable state of blood in patients with advanced gastric cancer by Chinese herbal compound.Methods:Collect 50 patients with advanced gastric cancer in accordance with the hypercoagulable state,and divide them into the experimental group and the control group using a random number table method,25 cases in each group.The experimental group took oral Jianpi Huayu Prescription combined with basic western medicine treatment(including gastric cancer chemotherapy and other symptomatic and nutritional support treatments).The control group had the same basic western medicine treatment plan,and treatment included gastric cancer chemotherapy and other symptomatic and nutritional support treatments.The subjects were visited on the first day of enrollment treatment(Visit 1),21±2(Visit 2),and 42±2(Visit 3)to collect various test data for effectiveness evaluation.Including changes in coagulation-related indicators(TF,VEGF,TT,APTT,FIB,DD),inflammation indicators(IL-1β,IL-6,IL-8,TNF-α),platelet activity(platelet aggregation function),and TCM symptoms Points and efficacy evaluation,KPS score.After entering the data,use SPSS 23.0 software for comparative analysis.Results:In the end,3 cases were dropped from the test group and 1 case from the control group.A total of 46 patients were completed(22 cases in the test group and 24 cases in the control group).(1)Blood coagulation function:After treatment with this prescription,the DD level of the test group was lower than that of the control group,which was statistically different(P=0.029<0.05);the FIB of the test group decreased more significantly than that of the control group,and the comparison between the two groups was significant There was a statistical difference(P=0.003<0.01);there was no statistically significant difference between the two groups of TT and APTT(P>0.05).(2)Tissue factor:After treatment,the TF level of the test group was slightly lower than that of the control group,but there was no statistical difference between the two groups(P>0.05).Before treatment,TF and DD were positively correlated(r=0.194),but the results were not different(P=0.174>0.05),TF and FIB were also positively correlated(r=0.447),and the results were significantly different(P=0.001<0.01);after treatment,at visit 3,the changes in the levels of TF and FIB in the test group were also positively correlated(r=0.433,P<0.05).(3)Vascular endothelial growth factor:After TCM treatment,the VEGF level of the test group was lower than baseline in visit 2 and lower than the control group.The difference was statistically significant(P=0.041<0.05).In visit 3,the levels of VEGF were statistically significant(P=0.041<0.05).The level of VEGF increased,and there was no statistical difference between the two groups(P=0.982>0.05).(4)Inflammatory factors:After treatment,the level of IL-1β in the experimental group decreased,while in the control group,there was a significant difference between the two groups(P=0.000<0.01);the TNF-α of the experimental group was lower than the baseline,and the control group was vice versa,And there is a significant statistical difference between the two groups(P=0.006<0.01).There was no statistically significant difference in IL-6 and IL-8 between the two groups(P>0.05).(5)Platelet aggregation function:After treatment,the ADP of the test group was.lower than that of the control group,but there was no statistical difference(P=0.354>0.05).(6)TCM syndrome score and curative effect:After treatment,the TCM syndrome score of the test group was significantly lower than that of the control group,with significant statistical difference(P=0.005<0.01);after treatment,the two groups of patients had no evaluation of the TCM syndrome curative effect Significant statistical difference(P=0.950>0.05).(7)KPS score:After treatment,the KPS score of the test group was slightly higher than that of the control group,but there was no significant difference in the KPS score between the two groups(P=0.358>0.05).(8)Safety evaluation:After treatment with this prescription,the experimental group and the control group had no statistics on the incidence of leukopenia,hemoglobin reduction,thrombocytopenia,increased transaminase ratio,increased creatinine,nausea and vomiting,diarrhea,etc.Academic difference(P>0.05).Conclusion:Jianpi Huayu Prescription has a good clinical effect.It can effectively improve the patient’s hypercoagulable state by inhibiting tissue factors,improve the symptoms of spleen and stomach weakness,Qi deficiency and blood stasis,regulate the inflammatory microenvironment in the patient,and has good safety. |
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