Observation On The Effect Of Yiqi Yangxue Huayu Recipe On The Hypercoagulable State Of Patients With Advanced Non-small Cell Lung Cance

Objective: To observe the clinical efficacy and safety of Yi Qi Yang Xue Hua Yu Prescription in patients with middle and advanced non-small cell lung cancer in the hypercoagulable state of blood,and to explore the therapeutic drugs and their mechanism of action in the hypercoagulable state of malignant tumors by traditional Chinese medicine.Methods: According to the diagnostic criteria of Western medicine and the differentiation standard of traditional Chinese medicine,60 patients with advanced non-small cell lung cancer were collected and randomly divided into treatment group and control group,with 30 cases in each group.The treatment group was generally treated with Chinese medicine to nourish blood and remove stasis,28 days for 1 cycle,and 2 consecutive cycles.The TCM syndrome score,quality of life score,serological D-dimer,FIB,PT,APTT,PLT index,blood routine,liver and kidney function and other safety indexes before and after treatment were observed,and statistical analysis was carried out.Results:(1)the efficacy of TCM symptoms;In the treatment group,7 cases were effective,16 cases were effective,7 cases were ineffective,a total of 23 cases were effective,and the effective rate was 76.67%;The control group was effective in 2 cases,effective in 8 cases,and ineffective in 20 cases,with an effective rate of 30.33%,and the difference was statistically significant(P<0.05).(2)KPS score:The KPS score of the treatment group was higher after treatment than before treatment.The difference in KPS scores between the two groups after treatment was statistically significant(P<0.05),and the treatment group was higher than that in the control group.(3)coagulation index;The values of D-dimer,FIB and PLT decreased after treatment in the treatment group compared with those before treatment.The differences in D-dimer,FIB values and PLT values after treatment between the two groups were statistically significant(P<0.05),and the treatment group was lower than that of the control group.There was no significant difference in PT and APTT between the two groups after treatment(P>0.05).(4)Khorana score: there was no significant difference between the two groups before and after treatment.In the intra-group comparison,the total risk value of the experimental group decreased after treatment,and the difference was statistically significant(P=0.021).In the control group,the total risk value increased slightly after treatment,but there was no significant difference(P=0.0756).(5)Adverse reactions: The general vital signs of the two groups before and after treatment were stable,and there were no toxic side effects in the heart,liver,kidney,etc.,and the related adverse reactions were few.Conclusion: Nourishing blood circulation and removing stasis can effectively improve the hypercoagulability of patients with advanced non-small cell lung cancer,reduce their symptoms and improve their quality of life.