Clinical Study Of Qingfei Huoxue Decoction On PTS And Pulse Diagram Of AECOPD With Phlegm-heat Obstructing Lung Syndrome

Objective: Through clinical observation,the clinical effect of Qingfei Huoxue Prescription on the PTS and pulse diagram of AECOPD with phlegm-heat plug lung syndrome was studied.At the same time,the effect was compared with the basic treatment of Western medicine,the mechanism of action was discussed,and the safety and adverse reactions of the prescription were monitored and analyzed,so as to give play to the advantages of traditional Chinese medicine in the treatment of AECOPD.Methods: A total of 72 ICU inpatients(20% abscission cases were considered in each group)who were admitted to the emergency department of Yunnan Hospital of Traditional Chinese Medicine from December 2019 to January 2021 were selected and randomly divide into treatment group and the control group with 36 patients in each group who met PTS of AECOPD phlegm-heat obstruction syndrome.The control group was given basic medical treatment,and the treatment group was given basic medical treatment plus Qingfei Huoxue Prescription.The course of treatment was 10 days.Treatment group and control group before and after treatment in patients with hemoglobin(Hb)and platelets(PLT),hypersensitive c-reactive protein levels(hs – CRP),fibrinogen(FIB),D-D dimer(D-D),the levels of homocysteine(Hcy),pulse diagram index(pulse strength h1,vascular tension h3/h1,peripheral resistance h4/h1,left ventricular systolic function t1)and the change of TCM syndrome integral and the comparison.Results:1.Before treatment,there was no statistical significance in age,gender,Hb,PLT,hs-CRP,FIB,D-D,Hcy,h1,h3/h1,h4/h1,t1 and TCM syndrome scores between the two groups(p > 0.05),suggesting comparability.2.There were significant differences in Hb,PLT,D-D and Hcy in the treatment group before and after treatment(p < 0.05).hs-CRP,FIB,h1,h3/h1,h4/h1,t1,TCM syndrome scores were significantly different(p < 0.01).3.There were significant differences in Hb PLT FIB and Hcy in control group before and after treatment(p < 0.05).hs-CRP,D-D,h1,h3/h1,h4/h1,t1,TCM syndrome scores were significantly different(p < 0.01).4.There was no statistical significance in Hb,PLT,h4/h1,t1 and TCM syndrome scores in two groups after treatment(p > 0.05).The hs-CRP,FIB,Hcy,h1 were significantly different(p < 0.05).D-D and h3/h1 were significantly different(p < 0.01).These results indicated that both groups were effective in the treatment of AECOPD patients with phlegm-heat obstructing lung syndrome in the prethrombosis state,but the therapeutic effect of the treatment group was significantly better than that of the control group.5.Evaluation of TCM efficacy: the total effective rate of the treatment group was 93.33%;The total effective rate of control group was 86.67%.The results of the two groups were significantly different(p < 0.05),indicating that the treatment group of TCM syndrome efficacy is better than the control group.6.Safety evaluation: intra-group comparison of liver and kidney function test results before and after treatment in two groups showed no statistical significance(p > 0.05).During the course of treatment,no significant changes were observed in vital signs,urine and stool routine and ECG.There were no obvious adverse reactions and toxic side effects during the experiment.Conclusions: Qingfei Huoxue Prescription interferes with the prethrombotic state and pulse diagram of AECOPD patients with phlegm-heat obstructing lung syndrome,and its clinical effect is better than simple basic medical treatment,and the effect is obvious and safe.