A Correlation Study Between Cognitive Dysfunction And Serum 1,25-Dihydroxyvitamin D₃ Level In Patients With Cerebral Small Vessel Disease

BackgroundCerebral Small Vessel Disease(CSVD)generally refers to the syndrome of clinical,imaging and pathological manifestations caused by various lesions of Small vessels.The latest CSVD categories include arteriosclerotic CSVD,sporadic or hereditary brain amyloidosis CSVD,non-amyloidosis hereditary CSVD,inflammatory or immune-mediated brain CSVD,venous collagen disease,and other small vascular diseases.With the acceleration of the global population aging,the burden of disease is also increasing,and the incidence of CSVD among the middle-aged and elderly is high and the burden of health and health economics is heavy.Always study found great vessels of cortical lesions caused by stroke is the main cause of vascular dementia,but with the deepening of understanding,find multiple subcortical small vascular disease is a major cause of vascular dementia,but at the moment of CSVD pathogenesis and related influence cognitive function in the results of the study is not yet clear,so it is necessary to carry out in-depth studyObjectiveA case-control study was conducted by clinical recruitment of volunteers,which was divided into groups according to the type of basic disease combined with CSVD,whether CSVD combined with cognitive impairment,and the type of CSVD,in order to explore the difference of serum 1,25-dihydroxyvitamin D3(1,25(OH)2D3)in different groups and its role in the pathogenesis.MethodBy raising 2018.12-2019.11 months the second hospital of Jilin university neurology memory clinic on 84 cases of patients with CSVD,collected from patients’ gender,age,level of education and other general demographic information,and biochemical examination,imaging examination,etc.,and using enzyme-linked immunosorbent(ELISA)to detect serum 1,25(OH)2D3,depending on the type of merger basic diseases with cognitive impairment severity and the same small cerebral vascular disease in patients with different severity 1,25(OH)2D3,To investigate whether the difference of 1,25(OH)2D3 between each group was statistically significant.Results1.The 84 subjects were divided into the normal control group,the diabetes group,the hypertension group and the hypertensive diabetes group according to whether they had diabetes or hypertension.The difference between the serum 1,25(OH)2D3 level and hypertension in the hypertensive diabetes group was statistically significant(P<0.05).There were no statistically significant differences in serum LDL-C,Hcy,hs-CRP,Ca2+and Mg2+between the groups(P>0.05)2.84 subjects were divided into the cognitive impairment group and the control group according to whether they had cognitive impairment(P>0.05).There were no statistically significant differences in gender,age,education level,smoking history or drinking history between the two groups.The serum Hcy level of the cognitive impairment group was higher than that of the control group,and the difference was statistically significant(P<0.05).The serum level of 1,25(OH)2D3 in the cognitive impairment group was lower than that in the control group,and the difference was statistically significant(P<0.05).The serum level of 1,25(OH)2D3 of the cognitive impairment group was compared with that of the normal control group,and the decrease of the serum level of 1,25(OH)2D3 of the moderate cognitive impairment group was significantly lower than that of the normal control group,the difference was statistically significant(P<0.05).The serum 1,25(OH)2D3 of the moderate and severe cognitive impairment group was lower than that of the mild cognitive impairment group.3.Eighty-four subjects were grouped according to the type of CSVD,and there was no statistically significant difference in the serum level of 1,25(OH)2D3 in patients with different types of cerebral microvascular disease(P>0.05).There were no statistically significant differences in LDL-C,hs-CRP,Ca2+,Mg2+,P and Hcy between the groups(P>0.05)Conclusion1.The serum level of 1,25(OH)2D3 in patients with cognitive impairment of cerebral microvascular disease is lower than that in patients without cognitive impairment of cerebral microvascular disease.Serum 1,25(OH)2D3 level was negatively correlated with the degree of small vascular cognitive impairment2.There was no significant difference in serum 1,25(OH)2D3 levels among patients with different types of cerebral microvascular disease.