| OBJECTIVETo study and analyze the effects of drinking and other risk factors on cognitive function in patients with cerebral small vessel disease,and to provide theoretical basis for reducing the risk of cognitive dysfunction in patients with cerebral small vessel disease and strengthening publicity and educationMETHODSA total of 140 patients with cerebral small vessel disease admitted to the first department of neurology in the Zhong Shan Hospital Affiliated with Dalian University from October 2016 to January 2018 were enrolled.All patients underwent head CT,MRI and cervical vascular examinations in the hospital.After detailed physical examination,the patient was diagnosed according to the 2015 "Chinese Cerebral Small Vessel Disease Diagnosis and Treatment Consensuse".The cognitive function status of all patients was assessed by Montreal cognitive assessment(MoCA).The score<26 was divided as cognitive dysfunction experimental group,a total of 69 cases;the score>26 was divided as normal control group of cognitive dysfunction,a total of 71 cases.The age,education level,drinking years,drinking severity,history of hypertension,history of diabetes,smoking history,body mass index(BMI),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),blood uric acid(UA)and other related risk factors of the two groups of cerebral small vessel disease patients are analyzed and compared,and then exist Multivariate Logistic regression analysis was used to determine independent risk factors for the development and progression of cognitive dysfunction in patients with CSVD.Spearman analysis was used to further analyze the association between the drinking severity,drinking years,and cognitive function in patients with CSVD.p<0.05 was considered statistically significantRESULTSThis study included 140 patients,69 cases in the experimental group,and 71 cases in the control group.50 cases(72.46%)of drinking in the experimental group:16 cases(23.19%)with mild alcohol consumption,16 cases(23.19%)with moderate alcohol consumption,18 cases(26.09%)with heavy drinking,17 cases(24.64%)with high drinking years and the level of education(6.61±3.13)years;and 21 cases(29.58%)of drinking in the control group:7 cases(9.86%)of mild drinking,6 cases(8.45%)of moderate drinking,8 cases(11.27%)of heavy drinking,7 cases(9.86%)of high drinking years,and education level(8.43±3.38)years.The two groups of patients were analyzed by t test and chi-square test,and there were differences in the education level,mild drinking,moderate drinking,heavy drinking,middle drinking years and high drinking years(P<0.05).Using cognitive dysfunction in patients with cerebral small vessel disease as a dependent variable,these differential factors as independent variables,multivariate Logistic regression analysis,the results suggest that mild drinking,moderate drinking,heavy drinking,high drinking years and the educational level were independent risk factors for cognitive dysfunction in patients with CSVD.The results of Spearman correlation analysis showed that there was a negative correlation between cognitive function scores and the severity of drinking in patients with CSVD(p<0.05,r=-0.623);In addition,there was a negative correlation between cognitive function scores and drinking years in patients with CSVD(p<0.05,r=-0.656)CONCLUSIONS1.Different degrees of drinking,high drinking years and low education level are independent risk factors for cognitive dysfunction in patients with cerebral small vessel disease2.The more severe the drinking and the longer drinking years of patients with cerebral small vessel disease,the more obvious the damage to cognitive function. |
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