Left To Pill For Liver And Kidney Deficiency Type Constipation Of Parkinson’s Disease Clinical Research

Objective:This study was to observe On the left to pill and subtract party belongs to the liver and kidney deficiency type of syndrome of Parkinson’s disease clinical curative effect of constipation,Methods:(1)Choose December 2016-December 2018 in wuhan city hospital of traditional Chinese medicine encephalopathy clinic patients,by Chinese and western medicine diagnosis,meet with western medicine in the diagnosis of Parkinson’s disease and constipation and TCM diagnosis of fibrillation syndrome of liver and kidney deficiency type,according to the inclusion criteria included in the 66 cases,divided into two groups by random indicator method,the treatment group 33 cases,control group 33 cases(eventually fall off in 1case,32 cases with complete data collection and statistics).The two groups before treatment in age,sex,constipation course,modified H-Y grading scores,equivalent daily dose levodopa(LDE)no statistically significant differences(P > 0.05),comparable.(2)The treatment group given out pill add and subtract(Produced by jiangyin day jiang pharmaceutical co.,LTD.Chinese medicine granules)oral,acceptable to add and subtract conventional western medicine treatment of Parkinson’s,the control group only accepted conventional western medicine treatment of Parkinson’s,a course of 4 weeks.Resistance to PD treatment of western medicine dose conversion according to the formula for equivalent dose levodopa,basic disease treatment is changeless,told other cathartic patients during treatment discontinuation,do not increase or decrease in oral medications or dietary changes and routine.(3)Collect patients defecation frequency,defecation time,endless defecate,abdominal pain and other symptoms,the chronic constipation symptom severity rating scale(CSS),constipation patients quality of life scale(PAC-QOL),Parkinson’s patients quality of life questionnaire(PDQ39)rate,and the evaluation before and after the treatment,and watch the test security.(4)Statistical analysis methods: all data application SPSS21.0statistical software for analysis.Measurement data meet or broadly in line with normal distribution using mean + /-standard deviation "(x±s)" said,using "t" test;Count data using "c2" inspection;Hierarchical data(disease classification comparison)using rank and inspection.There was no statistically significant difference(P>0.05)said when significant difference(P<0.05)said statistics.Statistical data are retain two decimal places,the percentage after the decimal point one.Results:(1)4 weeks after treatment,the treatment group healed in 2 cases,13 cases were markedly effective,effective 15 cases,invalid 3cases,the total effective rate was 90.9%;Control group clinical recovery and obviously effective 0 cases,5 cases effectiveness and27 cases,the total effective rate was 15.6%,two groups of efficient statistically significant differences(P < 0.05),and the treatment group is better than the control group.(2)The treatment group before and after treatment of constipation symptom severity score(CSS)(15.58±6.16,8.97±4.59),CSS score lower,significant difference(P < 0.05);Control group before and after treatment of CSS score(15.25±5.24,8.97±4.59),CSS score changes had no statistical significance(P > 0.05);And to compare the treatment group and control group after treatment of CSS score respectively(8.97±4.59,15.44±5.31)and significant difference between them(P < 0.05).(3)The treatment group before and after treatment of constipation patient quality of life scores(PAC-QOL)(78.09±22.47,47.67±32.29),the PAC-reduced QOL scores and significant difference(P < 0.05);The control group before and after treatment the PAC-QOL score(76.16±24.25,76.28±24.18),the PAC-QOL score changes without statistical significance(P > 0.05);And to compare the treatment group and control group after treatment PAC-QOL scores respectively(47.67±32.29,76.28±24.18)and significant difference between them(P < 0.05).(4)The treatment group before and after the treatment of Parkinson’s disease 39 questionnaire score(PD39)(41.06±19.74,31.36±16.94 mm),PD39 score lower,significant difference(P <0.05);Control group before and after treatment PD39 score(39.41±18.43,30.41±16.05),PDQ39 score also significantly decreased and significant difference(P < 0.05);But PDQ39 score differences between the two groups after treatment has no statistical significance(P > 0.05).(5)As to the security,the treatment group and control group in the study were no serious adverse drug reactions occurred,shall not affect the proceeding of the test.Conclusion:(1)The left to pill can significantly improve the liver and kidney deficiency type constipation symptoms of Parkinson’s disease patients with constipation and constipation related quality of life,and use conventional western medicine treatment of Parkinson’s resistance is not the role.(2)Conventional western medicine treatment of Parkinson’s liver and kidney deficiency type of Parkinson’s disease can be improved the overall quality of life(PDQ39 score lower),but left to pill and subtract this role or nothing further enhance this effect.(3)The left to pill for treatment of liver and kidney deficiency type constipation in patients with Parkinson’s disease good security.