Wanwan Bi Kang Pill Treatment The Yin Deficiency Of Liver And Kidney Of The Rheumatoid Arthritis To Observe The Clinical Efficacy

Objective:Observation of obstinate Wanbi-Kang pill in treating liver-kidney Yin deficiency clinical effects of RA, simultaneous observations of the parties on the RA clinical safety, clarify the prescription of tonifying liver and kidney clear Interior heat and the effect and mechanism of treatment of RA, to nourish liver and kidney, check and return deficiency-heat therapy for RA to provide theoretical basis, Foundation for treatment of RA for the development of efficient and safe natural medicines.Methods:According to a randomized, parallel-controlled, single-blind clinical trial principles, winning90cases consistent with the diagnosis of rheumatoid arthritis, as well as meeting the criteria of liver-kidney Yin deficiency syndrome based on syndrome differentiation of traditional Chinese medicine in patients.90cases patients random is divided into three group, which treatment group30cases, to methyl ammonia Butterfly Yin tablets+non-steroid body anti-inflammatory drug (beauty Los ever Kang capsule)+obstinately wan bi kang pills treatment; against1group30cases, to methyl ammonia Butterfly Yin tablets+non-steroid body anti-inflammatory drug (beauty Los ever Kang capsule)+glucosides total Glycoside capsule treatment, against2group30cases, to methyl ammonia Butterfly Yin tablets+non-steroid body anti-inflammatory drug (beauty Los ever Kang capsule) treatment, course are for1months.Results:①treatment Hou three group case effect comparison (used ACR standard), treatment group reached ACR70standard, and ACR50standard and the ACR20standard respectively for0cases, and9cases and the17cases, total effective rate86.6%; against1group reached ACR70standard, and ACR50standard and the ACR20standard respectively for0cases, and5cases and the10cases, total effective rate up50%; against2group reached ACR70standard, and ACR50standard and the ACR20standard respectively for0cases, and In3cases and12cases, total effective rate of50%. All three groups did not1month treatment cured cases. Difference statistically rank sum test (P＜0.01).②treatment Hou three group in card waiting effect comparison, treatment group clinical mitigation, and having and the effective cases number respectively for16cases, and8cases and the3cases, total effective rate90%; against1Group clinical mitigation, and having and the effective cases number respectively for10cases,6cases, and the7cases, total effective rate up76.6%; against2Group clinical mitigation, and having and the effective cases number respectively for8cases,9cases, and the7cases, total effective rate up73.3%; three group are no1months treatment recovered of case. Proven difference statistically significant (P＜0.01).③on clinical outcome measures, after treatment, the treatment group and the control group overall mitigation and elimination of symptoms and signs of patients with inflammatory activity, and has curative effect indicator (P＜0.05). Comparison between treatment and control group1, index of groups treated with ESR, CRP compared with control1group no gaps (P＞0.05) and compared with the control2group, a significant difference (P＜0.01). In terms of joint pain, treatment is superior to control1group and the control group2(P＜0.01), in terms of swelling, treat and control1group and the control group2significant difference (P＜0.05). Falls in three sets after treatment, patients on pain assessment, overall assessment of disease activity in patients with overall evaluation of HAQ, doctors on disease activity index, treatment and control1group and the control group2significant difference, rheumatoid factor, morning stiff time compared three groups of indicators are meaningless (P＞0.05). Three groups of patients with no apparent adverse reaction, three groups of no statistically significant adverse drug reactions after treatment (P＞0.05).Conclusion:Obstinate wanwan bi kang pill in treating RA liver and kidney Yin deficiency of total glucosides of Paeony in treating or methotrexate in the treatment of simple effect more pronounced in improving symptoms, in controlling inflammatory disease activity index has also demonstrated efficacy. And with no apparent side effects.