Clinical Analysis In 43 Syndrome Of Inappropriate Antidiuretic Hormone Secretion

Objective : We were retrospectively analyzed the clinical data of 43 syndrome of inappropriate antidiuretic hormone secretion,to improve the diagnosis and treatment of the disease.Methods:We were retrospectivelyanalyzedtheclinical manifestations,laboratory tests,imaging studies,pathological examination and treatment and other clinical data of the patients with SIADHinGuangxiMedical University First Affiliated Hospital,from June 2012 to December 2016.Patients were divided into A and B groups according to the level of serum sodium when SIADH was diagnosed.Patients with 120 mmol / L <serum sodium <135 mmol/ L were included in group A and patients with serum sodium ? 120 mmol / L were included in group B.Result:There were 43 patients with SIADH,29 males and 14 females with an average age of(55.98 ± 15.42)years.1.There was no significant difference in sex,age,primary disease and clinical manifestation between group A(120 mmol/ L <serum sodium <135 mmol / L)and group B(serum sodium ? 120 mmol / L)(P> 0.05).2.Malignant tumors accounted for 32.56% of primary disease of SIADH.3.the primary symptoms and signs accounted for 46.51% of SIADHclinical manifestations,followed by,the symptoms with fatigue and loss of appetite accounted for 30.23%.4.The serum sodium level was significantly higher than that before treatment(P <0.05),and there was significant difference between the two groups before and after treatment(P <0.05).Conclusion : 1.There are a variety of causes can lead to syndrome of inappropriate antidiuretic hormone secretion,which is a more common cause of malignant tumors.2.SIADH clinical manifestations of non-specific,often manifested as primary symptoms,followed by theperformance of fatigue and poor appetite.3.simply supplemented with hypertonic saline,limited intake,appropriate supplementation of hypertonic saline,diuretic combination therapy,simply using tolvaptan treatment are very effective for SIADH.