| Objective We study to understand the pathogenesis of children with autism,and learn some causes of autism spectrum disorders through comparing with normal children in all aspects of the influence factors,aiming of providing a scientific basis for prevention and treatment of autism spectrum disorders.Methods Using the method of 1:1 case control studies to have a retrospective investigation.We choose the children with autism as observation group in Child care division of hospital from May 2014 to May 2015;while selecting children which development normal into control group in the same period,matching the age and gender group between the two groups.The diagnosis of autism is based on the United States of the diagnostic and statistical manual of mental disorders of fifth edition(DSM-5),and at the same time using the Autism Behavior Checklist(ABC)and Childhood Autism Rating Scale(CARS)to evaluate how sick the autistic children is.Using the questionnaire about children' health and health influencing factors we surveyed the two groups for recycling effective questionnaire and verify the data,Epi Data3.1 software is adopted to establish the database,then using the statistical software of Stata12.0 for single factor analysis and conditional logistic regression analysis,to contrasting the differences between two groups.Results 1?The general situation: the observation group included 98 cases of children with autism,the control group is also 98 cases of children,with 82 cases male,female 16 cases,the sex ratio was 5.1:1.The average months of cases was(51.41±24.35)months,average height of cases was(103.60±15.83)cm,and the average weight was(17.59±5.26)Kg,the difference was not statistically significant(P>0.05)compared with control group.Average head circumference of autistic children was(50.03±1.77)cm,and it is greater than the control group(49.33 ± 2.25)cm,difference has statistically significant(t=2.41,P=2.41).2?Rating scale: cases in the ABC rating scale has highest score of 128 points and the lowest scored of 24 points,the average points was(67.2±67.2)points.The scores of ABC scale and the average score of its five dimensions functional classification including perception S,communication R,somatic movement B,language L,and self-care ability s,there were no statistically significant difference(P>0.05)between men and women;According to the results of CARS rating scale,There were 58 cases of 98 cases of children with autism whom were diagnosed with mild-to-moderate autism,40 people were diagnosed with severe autism;The average scores of CARS scale in comparing differences between men and women there was no statistical significance(P>0.05),but how sick autism in the comparison between different gender difference was statistically significant(P<0.05).3?Single factor analysis: the differences of exposed ratio in the case group and control group has statistically significant(P<0.05)in the following influence factors:the hospital medical history of children,pathological jaundice,febrile convulsion,picky about food,one eye recognition understanding ability and so on;In the parents and family influence factors,exposure rate of mothers older than 35 years old,mother's education,his father engaged in labor type,family relationship,and having a family history of diseases between the case group and the control group has differences;The risk factors of during mother pregnancy and the perinatal period by matching the Mc Nemar test which was statistically significant was the supplements,emotional irritability,mental stimulation,normal pregnancy vomiting,history of illness during pregnancy,normal fetal movement,and the way of delivery,labor time,feeding mode,and so forth,P value is less than 0.05.4?Conditional logistic regression analysis: the regression coefficients were statistically significant in Children' own factors of children' eye recognition and understanding and head circumference significant,regression coefficient of children' eye recognition and understanding was(?=-3.077,P=0.000),head circumference of the regression coefficient was(?=0.341,P=0.028).While other factors fixed,head circumference 1 cm per exception,children' disease probability will increase 1.406 times.In the Parents and family factors,mother older than 35 years old,family relationship,a family history of neurological disorder diseases,father engaged in labor type four variables had significant difference of regression coefficient test,regression coefficients and the OR value respectively were(?1=1.297,P=0.038,OR=3.659;?2=3.679,P=0.000,OR=39.612;?3=1.726,P=0.028,OR=5.621;?4=-2.190,P=0.022,OR=0.112),there was significantly correlation with the occurrence of diseases;in the factors of period of the mother pregnancy and perinatal pregnancy,variables' regression coefficient was as follows,mood irritability(?=1.966,P=0.024,OR=7.144),and mental stimulation(?=2.067,P=0.008,OR=7.902)and pregnancy vomiting(?=2.576,P=0.012,OR=13.138),these regression coefficient was greater than zero and there were statistically significant,and they were positively to associated with the occurrence of diseases;But supplements(?=-2.435,P=0.001)and normal fetal movement(?=-2.008,P=0.009)were negatively associated with autism,exposure odds ratio was 0.088 and 0.134.Conclusions If mother is elderly parturient women,and has pregnancy vomiting phenomenon pregnancy and also easily irritable,indeed suffering serious mental stimulation,all these risk factors may cause certain damage to the fetal nerve and functional development during the fetus;Factors of disharmonious relations of family,a family history of neurological disorder disease,father often engaging in physical work,may increase the risk of autism disorder.If the mother have a baby before the age of 35,and have supplements timely during pregnancy,keep happy every day,the fetus will have a good start to grow.After the child birth,let him grow in a family environment full of harmony,and during young children period parents take more attention to the child's language communication,head circumference and other indicators of development,to strengthen the training of cognitive ability,to discover the problem in time,and for intervention treatment.At the same time,in the process of children grow up parents increase a lot of time to keep them company,to a certain extent,can reduce the risk of autism. |
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