| Objectives:To improve the early study on the application of autism screening scale(CHAT-23) of our research group and to carry on the extended study of the checklist.Methods:1) To screen children aged 18-24 months for ASDs with CHAT-23 in Longhua street and Xietu street of Xuhui District.2) Autistic children were recruited as the patient group, and normal children were recruited as the control group. SPSS 13.0 was used to analyse the reliability and validity of the checklist.3) The 11 detected abnormal children in the early study were followed up at intervals of three months.Results:1) Among the total 770 children screened, we found 1 child diagnosed as autism. The prevalence of autism was 1.3/1000.2) Reliability analysis:the split-half reliability:the coefficient of the whole scale was 0.847,the Cronbach's a coefficient:the coefficient of the whole checklist was 0.817.3) Validity analysis:content validity:the correlation coefficients between items and whole checklist were ranged from0.018 to 0.676. Construct validity:6 public factors were extracted by principal component analysis, which defined the 59.85% of the full variant. Discrimination validity:There were difference in the total scores between children in patient group and normal children, and this difference was statistically significant.Conclusions:The reliability and validity of this checklist is good enough for the early detection of autism spectrum disorders. Objectives:To screen for autism spectrum disorders (ASDs) among preschool children attending four kindergartens in Shanghai by using Social Communication Questionnaire (SCQ) and to evaluate the validity of Social Communication Questionnaire (SCQ) as the primary screening instrument in ShangHai China.Methods:In this study, SCQ was completed by parents of children attending four kindergartens in Shanghai. To calculate the sensitivity and specificity of the SCQ, Autism spectrum disorders children were recruited as the patient group, the non-ASDs children participating in the screening were selected as the control group.Results:Among the children screened,2 children were found to show a high risk for ASDs. In our sample, the suspected prevalence of ASD was 2.3/1000. The sensitivity and specificity of SCQ were 0.74 and 0.93.Analysing the distribution of SCQ scores and the response pattern of items, we found that total SCQ scores ranged from 0 to 20,with a mean of 8.74 and SD of 3.9,and nearly normally distributed. Some items on the questionnaire were answered as 'autism-positive' for up to 70% of children in the control group and surpassed the patient group.Conclusions:The cutoff score recommended by the SCQ manual may be not suitable for using in primary screening. Lowering the cutoff score may improve the validity. Some items in the SCQ are not useful to discriminate children with ASDs from other non-ASD children. Objectives:To explore the clinical characteristics and risk factors of autism, in order to provide scientific basis for early detection and diagnosis of autism.Methods:192 cases of autistic children which were diagnosed between 2004 November and 2010 August had been collected in this article. All these 192 cases were studied about chief complaint, clinical manifestation, personal history and family conditions (pregnancy, family, parents educational background, parents disposition, household education) and assistant examinations (CT/MRI,EEG,BAEP).Results:Among the 192 cases,21 cases(10.9%) were less than two years old. The language developmental disability was the mainly chief compliant, especially have no language (62%).During gestational period and childbirth time,85 cases(44.3%) has adverse factors.52 cases(27%) has abnormal family history. Among the assistant examinations, an especially high abnormality was found in EEG.Conclusions:Parents often paid highly attention to language developmental disability. In order to improve the early detection of childhood autism, it suggested that social development should be included in routine health check-up and should be taken seriously. There was relationship between the abnormality of pregnancy, birth, family, father's introverted personality and the pathogenesis of autism. The EEG test is highly recommended for autistic children.
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