| Cough variant asthma is considered to be precursor performance ofasthma, and it is a special type of asthma，which is also called allergic coughor occult asthma or cough type asthma, It often occurs in pre-school studentsand school students, and also occurs in infants. Clinical manifestations are drycough,less or no sputum, pharyngeal itching,and it often has recurrent attacksor lasted over1month. It.often occurs in spring and autumn. It is ofteninduced by respiratory infections, exercise, fume, cold air, and so on. Thedisease is a very common clinical respiratory diseases with high incidence,and is gradually becoming the research focus. Recent studies showed thatcombining Traditional Chinese Medicine with western medicine to treat CVAhas greater advantages than through western medicine alone,which can alsoimprove the symptom and the living quality of the patients.Objective:Observe the effectiveness of the treatment of CVA in childrenutilizing Dingchuan decoction joint Montelukast Sodium chewable tablets.Objective:Observe the clinical efficiency of the treatment ofDingchuan decoction joint Montelukast Sodium on infantile coughvariant asthmaMethods:1All outpatients with cough variant asthma who were selected from theChinese Medicine Hospital affiliated to Hebei Medical University.Anddiagnosed CVA and belonged to lung wind cough syndrome.The observationcourse of both groups all lasted4weeks.2Strictly abide by the inclusion criteria and collected40cases,dividedthe40patients into treatment group (Traditional Chinese Medicine jointwestern medicine)and control group(western medicine alone) by completely randomized principle, The treatment group and control group are all20cases.Treatment group was given Dingchuan decoction joint Montelukast Sodiumchewable tablets treatment. Traditional Chinese Medicine using particles fromFried preparation. One dose and two times a day..The oral methods of theMontelukast Sodium chewable tablets （Hangzhou Merck Sharp&DohmeLtd.）<6years old4mg,6~12years old5mg,>12years old10mg,one timeevery night. Control group was only given Montelukast sodium treatment.Taking method is as same as the treatment group.Observe the changes of twogroups in the total clinical efficiency, the score of TCM syndrome andperipheral eosinophil count aspect.Results:1The comparison of total clinical efficiency:the comparison of totalclinical efficiency of the two groups, In the treatment group,9cases werecured,7cases had marked effect,3cases had effect and1case was noteffective. The total effective rate was95%;in the control group,5cases werecured,6cases had marked effect,5cases had effect and4case was noteffective.The total effective rate was80%; After statistics analysis, thecomparison of the two groups has significant differences(P<0.001); thetreatment group is better than the control group.2the comparison of the total score of TCM Syndrome between the twogroups: After repetitive measurement and analysis of variance, the resultshowed that the interaction effect was statistically significant(P＜0.05); Wecan find out that the trends of the total score of TCM syndrome of the twogroups is different,the average difference of total score of the treatment groupis higher than the control group.So prompt the effect of treatment group isbetter than the control group.3the comparison of the single TCM syndrome:①the comparison of the symptoms as cough degree and itchy throat,After repetitive measurement and analysis of variance, The result showed thatthe interaction effect was statistically significant(P＜0.05); We can find outthat the trends of the score of syndromes of cough degree and itchy throat of the two groups is different,the average difference of the treatment group ishigher than the control group.So prompt the effect of treatment group is betterthan the control group.②the comparison of the symptom scores of the quantity of phlegm,pharyngeal, body of the tongue,coated tongue, pulse condition:After repetitivemeasurement and analysis of variance, the result showed that the interactioneffect of the five index was not statistical significant(P＞0.05），We can thinkof the trends of the score of the five index is the same.There was no statisticalsignificant difference between the two groups.4the comparison of count of the peripheral blood eosinophils(EOS):Afterrepetitive measurement and analysis of variance, The result showed that theinteraction effect was statistically significant(P＜0.05); the average differenceof the treatment group is higher than the control group. so prompt the effect oftreatment group is better than the control group.Conclusions:The effect of Dingchuan decoction joint MontelukastSodium chewable tablets. is better than only use Montelukast Sodiumchewable tablets alone at the aspects as total clinical efficiency, the totalscores of TCM syndrome, cough degree, itchy throat, and the peripheral bloodeosinophils, on the.treatment of infantile CVA.The result showed that on thebasement of conventional western medicine united traditional Chinesemedicine has significant advantages, and it provides a new treatment optionson the treatment of this kind of disease. |
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