The Clinical Observed Of Modified Rehmanniae Decoction Of Six Ingredients Treat With Elderly Hypertension

Objective:Objective evaluation of modified Rehmanniae Decoction of six ingredients in treatment of elderly hypertensive patients (two of yin and yang deficiency and blood stasis) clinical efficacy, and its security is evaluated.Methods:In accordance with Chinese and Western medicine diagnosis standard, choose hypertension60cases which Met the inclusion criteria, to take a random stratified method, divided into the treatment group and the control group with30cases in each group, the two groups in age. gender, underlying illness, no significant differences. Control group use amiodipine (5mg po, qd) combined with Irbesartan (150mg po, qd), treatment group on the basis of the control group,plus modified Rehmanniae Decoction of six ingredients of300ml(100ml each time,tid),taking14days.Before and after treatment were observed in patients with various checking index, finally using statistical methods work out the therapeutic efficacy.Result:The treatment group hypotensive total efficiency of93.33%, higher than73.33%in control group, P<0.05. The day blood pressure contrast, the results of two groups after treating systolic blood pressure, diastolic blood pressure, pulse pressure is lower before treatment, P<O.01; Comparison between groups, lower systolic significantly better than control group, P<O.01, diastolic blood pressure, pulse pressure lower than in control group, P<O.05; The treatment group than in control group also blood pressure range. Dynamic blood pressure result comparison with that,after treatment between the two groups average systolic blood pressure, the night by average systolic blood pressure and24hour average systolic blood pressure than in control group, P<O.01; daytime average diastolic blood pressure and night average diastolic blood pressure,24hour average diastolic blood pressure reduce significantly better than control group, P<0.05;Pulse pressure drop than in control group, P<0.05. The treatment group than in control group mainly single symptoms improve, P<0.05.Syndrome integral also obviously lower than the control group, P<0.01. Syndromes improve treatment group total effectiveness93.33%, better than control group,66.67%, P<0.05.blood lip compared before after treatment had no significant difference, P>0.05.Blood fat before and after treatment no obvious difference contrast, P>0.05. Before and after treatment all safety index no difference.Conclusion:The curative effect in treatment group was superior to the control group, with six treated elderly hypertensive patients(two of yin and yang deficiency and blood stasis) is safe, effective, worthy of further research and application.