Experimental Study Of Baishaoqiwu Granule In The Treatment Of Ulcerative Colitis

Objective:Experimental study to explore the therapeutic effect and mechanism of action of Baishaoqiwu Granule of ulcerative colitis, provide a theoretical basis for the Baishaoqiwu Granule provide further through the Chinese medicine treatment of ulcerative colitiscertificate of medical evidence, as well as ideas and methods.Methods:60rats were randomly divided into into normal group, model group, mesalazine slow release particles dose group, Baishaoqiwu granule high-dose group, Baishaoqiwu granule medium-dose group, Baishaoqiwu granule of low-dose group, in addition to the normal group, other groups with TNBS/ethanol model, successful modeling gavage, rats general, weight change, stool, blood in the stool;14days after the administrationmeasured serum levels of TNF-a, IL-10levels; take the colonic mucosa CMDI score and take the obvious lesion area to do a biopsy and pathology.Results:Baishaoqiwu granule, the middle dose group can significantly improve weight loss in rats, compared with model group, P<0.01.2、 Baishaoqiwu granule,the high and the middle dose groups can significantly reduce the UC rats CMDI score, compared with model group, P<0.01.3、Baishaoqiwu granule,the high and the middle dose could significantly reduce the UC serum TNF-a content, an increase of UC serum IL-10levels, compared with model group, P<0.01.4、Biopsy, Baishaoqiwu granule,the high and the middle dose groups can significantly improve the local mucosa injury and inflammation of rats with UC.Conclusion:Baishaoqiwu granule, dose can be significantly improved symptoms of rats with UC, repair of the intestinal mucosa, and significantly reducing the content of uc model of colon tissue in rats pro-inflammatory cytokines TNF-a, increase anti-inflammatory cytokine IL-10content by adjusting the balance of pro-inflammatory cytokines and anti-inflammatory factors play a role in the treatment of ulcerative colitis.