Meta-analysis On Influencing Factors Of Cervical Cancer And The Case-control Study On Risk Or Predisposing Factors Of Cervical Cancer In Jiangxi Area

Objective:①Comprehensive evaluation the influencing factors of cervical cancer by using Meta analysis;②To explore risk factors of cervical cancer in Jiangxi area, provide evidence for prevention and control for the area.Methods:①Through search Chinese (WANFANQ CNKI, VIP) and English (PUBMED CENTRAL, SCIE and OVID)database, according to the inclusion and exclusion standard collect data and using Meta software to analysis the influencing factors. Counting material using odds ratio and 95% confidence interval to express the intervention results.②Thoose 70 CC and 70 controls, which are diagnosed in the first affiliated hospitals or Jiangxi tumor hospital from April to December in 2009 by pathology, using multiariate analysis all influencing factors.Results:①There are 19 references included, all of which are case-control study. 26493 people are included in the research object.The cases include 6908 patients and controls include 19585. All are ended by odds ratio.②According to Meta analysis: HPV infection, more pregnant and prolific, more sexual partner, little age of the first sex and birthing, smoking may increase the risk of cervical cancer, which are agree with the recent research. Oral contraceptives and marry age have nothing to do with cervical cancer, and hingh level of education may decrease the risk of cervical cancer.③According to funnel graphics, this study exsited published bias, but have no substantial influence on the results.④Between study and control group, there were no significant difference in the age, native place,address and nation;⑤Single factor analysis indcated 35 factors relate to cervical cancer, including 22 risk factors and 13 protective factors; Results of multivariate logistic analyses suggested 6 risk factors,there are HPV,unhappy marital life, irregular vaginal hemorrhage, sexual intercourse hemorrhage, often had salted foods, husband long wrapping; and two main protection factors, high education level and the age of first sex > 25;⑥Comprehensive analysis indcate:besides HPV, the infection rate of which is 90%,more pregnant and birth, more sexual partner, cervical ectropio, unfortunate incident, often eat salted food, housing nervous and husband primarily physical labor,are may new risk factors in the region Except recognized cervical cancer protection factor, high education, primarily mental work, good economic condition, often have fresh fish, satisfaction and husband often washing after sex may decrease the prevalence of cervical cancer in the region.Conclusion:①According to Meta analysis:HPV infection, more pregnant and prolific, more sexual partner, little age of the first sex, and birthing, smoking may increase the risk of cervical cancer. Oral contraceptives and marry age have nothing to do with cervical cancer, and hingh level of education may decrease the risk of cervical cancer.②CCS analysis: besides HPV, more pregnant and birth, sex disorder, cervical ectropio, unfortunate incident, often eat salted food, housing nervous and husband primarily physical labor, are may new risk factors in the region Except recognized cervical cancer protection factor, high education, primarily mental work, good economic condition, often have fresh fish, satisfaction and husband often washing after sex may decrease the prevalence of cervical cancer in the region.