Cervical Cancer Risk Factor In Relatioto The Three Type Of Meta-Analysis

Objective: Meta-analysis used to evaluate the three type of risk factors,including:(1) Biological factors: High-risk human papilloma virus (HR-HPV)infection;(2) Behavioral factors: Early of first sexual, Multiple sexual partners,Many times of vaginal delivery, Many times of induced abortions, Long-termuse of Oral Contraceptives (OC) and Second Hand Smoking (SHS);(3) Geneticfactors: Family history of gynecologic cancer. The relationship of CervicalCancer (CC).Methods: The relationship between the three type of risk factors forcervical cancer through a computer search collect from January2001to March2014at home and abroad, including Chinese and English, search China JournalNet CNKI Chinese Academic Journal, Wan Fang DATA, VIP ChineseScientific Journals database, Pubmed database and Embas database. Publishedresearch literature on three type of risk factors for cervical cancer, by the nameof the researcher to extract data based on inclusion and exclusion criteria andgather relevant case-control study (CCS) literature, with a comprehensiveMeta-analysis methods analysis of count data using odds ratios (OR), as theeffect of the value of influencing factors to OR,95%Confidence Interval (CI) represents the amount of each effect section range. There are8factors extracted:①HR-HPV infection;②Early of first sexual;③Multiple sexual partners;④Many times of vaginal delivery;⑤Many times of induced abortions;⑥Long-term use of Oral Contraceptives (OC);⑦Second Hand Smoking（SHS）and⑧Family history of gynecologic cancer. The information ofincluded studies data. The experimental data were provided by CochraneCollaboration Rev Man5.2software for statistical analysis.Results: The final included18case-control literature, Among them haveChinese literature, Chinese literature4Papers and English literature14Papers.the study has5.187cases, including control has8.642cases. The result forMeta-analysis:1. Biological factors: HR-HPV infection, the combined effect size OR was128.38,95%CI（75.43,218.51）, P＜0.001，The difference was statisticallysignificant.2. Behavioral factors: Early of first sexual, the combined effect size ORwas1.87,95%CI (1.66,2.11), P＜0.001，the difference was statisticallysignificant. Multiple sexual partners, the combined effect size OR was2.30,95%CI (2.04,2.58), P＜0.001，the difference was statistically significant. Manytimes of vaginal delivery, the combined effect size OR was1.86,95%CI (1.68,2.06), P＜0.001，the difference was statistically significant. Many times ofinduced abortions, the combined effect size OR was1.42,95%CI (1.17,1.71),P＜0.001，the difference was statistically significant. Long-term use of OralContraceptives (OC), the combined effect size OR was1.85,95%CI（1.55,2.22）, P＜0.001，the difference was statistically significant. Second HandSmoking, the combined effect size OR was4.03,95%CI（3.20,5.08）,P＜0.001，the difference was statistically significant. 3. Genetic factors: Family history of gynecologic cancer, the combinedeffect size OR was1.83,95%CI（1.13,2.98），P＜0.05，the difference wasstatistically significant.Conclusion: This research three broad type factors of the result for Meta-analysis: HR-HPV infection is the major risk factor for cervical cancer. Early offirst sexual, Multiple sexual partners, Many times of vaginal delivery, Manytimes of induced abortions, Long-term use of Oral Contraceptives, Second HandSmoking and Family history of gynecologic cancer are risk factor for cervicalcancer. In clinical the above conclusions can be applied guide the women’shealth of Education and thus play role of the early prevention of cervical cancer.