| Objective: Dietary factors are closely related to any type of cancer,especially it is closely related to colorectal cancer.However,due to changes in the number of diets,patterns and cooking methods,there are different conclusions on the impact of these dietary components on the risk of colorectal cancer.This study aims to comprehensively explore the relationship between diet-related factors and the risk of colorectal cancer through bibliometrics,case-control studies and meta-analysis.Methods: Retrieve publications on diet and colorectal cancer risk research from Web of science.Use VOS Viewer 1.6.14 software for bibliometric analysis.The network map is used to evaluate the co-occurrence of key words and cooperation between different countries and institutions.A hospital-based case-control study was conducted in three hospitals from 2009 to 2011.The patients in the study were individually matched by age,gender,and city of residence.The study ultimately included 833 cases of colorectal cancer.A structured questionnaire was applied to collect demographic and dietary information through face-to-face interviews.To explore the relationship between solanaceous vegetables and the risk of colorectal cancer,unconditional logistic regression was used to calculate odds ratios(OR)and 95%confidence intervals(CIs).We systematically searched Pubmed’s articles from the beginning to 2020,and identified related articles on tomato and potato intake and the risk of colorectal cancer.Based on the heterogeneity,a random model was used to aggregate the included evidence,and a subgroup analysis was performed to test the differences between different groups.The stability of the research results was tested by sensitivity analysis.Publication bias was also assessed by Egger’s test.Results: A total of 3779 articles related to diet and colorectal cancer risk research were retrieved.We have observed that since 1990,the number of publications has continued to increase.The United States is a major contributor in this field,publishing1,636 papers.Active cooperation between countries and institutions was observed;throughout the case-control study,there was no significant association between total Solanaceae plant intake and the risk of colorectal cancer.The adjusted OR of the maximum intake and the minimum intake was 2.97(95% CI: 1.40,6.28,P=0.028).A significant inverse correlation was found in the analysis of specific solanaceous vegetables,including eggplant(OR = 0.27;95% CI: 0.18-0.41),sweet pepper(OR =0.54;95% CI: 0.38-0.75)and tomato(OR=0.53,95%CI: 0.33-0.85).In the sex stratification analysis,eggplant and sweet pepper still had a significant protective effect(P<0.05).In the stratified analysis of cancer subsites,eggplant had no protective effect on distal colon cancer(OR=1.14,95%CI: 0.47-2.77);the results of meta-analysis showed that tomato consumption was related to the prevention of colorectal cancer(RR=0.73;95%CI:0.60-0.89),while the consumption of potatoes is not associated with the risk of colorectal cancer(RR=1.09;95%CI:0.95-1.25).Conclusion: Since 1990,articles on diet and the risk of colorectal cancer have increased year by year,and the United States has contributed the most publications.There is active cooperation among authors,countries and institutions.Further research should expand and develop new themes,such as those that may reduce the risk of cancer.This study did not find that the consumption of nightshade vegetables in northeastern China is associated with a reduction in the risk of colorectal cancer,but certain types of nightshade vegetables may have a protective effect on specific subgroups of cancer.The results of the meta-analysis showed that the consumption of tomatoes can prevent colorectal cancer,and the consumption of potatoes is not associated with the risk of colorectal cancer. |
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