The Study On Risk Factors Of Cervical Cancer In Wudu District Of Gansu Province

Objective:This thesis investigates the risk factors of cervical cancer in Wudu, Gansu, aiming at determine the best methods to prevent cervical cancer, thereby reducing the morbidity and mortality of cervical cancer. Methods:A case-control study is conducted between a case group and a control group. The study sets183patients with cervical carcinoma who are diagnosed and treated in3hospitals in Wudu, Gansu since March2009to May2012as a case group. It investigates366patients from those who take outpatient line health examination as the control group by using a questionnaire including age, marriage, occupation, education, income, smoking history, contraceptive history, gynecologic history, family history of cancer, sexual behavior, reproductive system tumors such as the history of spouse. The screening of cervical cancer risk factors in this region is got using the software of STATA3.1data homogeneity test and SPSS13.0statistical software for data conditional Logistic regression analysis. Results:The result of single factor analysis shows significant variables are the following:high-risk HPV infection, smoking history, family history of cancer, age at first sexual intercourse, age of first pregnancy, induced abortion times, production number, spouses with phimosis、carcinoma of penis, condom use and partner circumcision. Logistic regression analysis shows that cervical cancer morbidity is significantly associated with high-risk HPV infection (OR=20.971, P<0.01), age at first sexual intercourse (OR=4.314, P<0.01) and smoking (OR=3.177, P<0.01), and that cervical cancer morbidity is also correlative to induced abortion times(OR=2.451, P<0.01), production number (OR=,2.375, P<0.01) and spouse with phimosis (OR=2.138, P<0.01). Condom use (OR=0.447, P<0.01) and circumcision (OR=0.513, P<0.01), are factors for the prevention of the cervical cancer morbidity. Conclusion:high-risk HPV infection is the main factors of high morbidity of cervical cancer in Wudu, Gansu, with early age at first sexual intercourse and smoking the main correlative factors. The use of condoms and circumcision are preventative factors that can reduce the cervical cancer morbidity.