The Clinical Observation In Shen Kang Jiang Suan Particles To Gouty Nephorpathy Of Influence To GAL/NAG And XOD

Objective: To observe the treatment of Shen kang jiang suan granules spleen and kidney deficiency, two wet chaotic blood stasis syndrome gouty nephropathy clinical curative effect.Methods: will comply with the diagnosis and into the standard 63 gouty nephropathy patients were randomly divided into the treatment group and control group, including the treatment group (33 cases in treatment group give Shen kang jiag suan granules, daily a dose oral; sooner or later, points twice The control group 30 cases give oral) received allopurinol 100mg, once three times. Treatment are eight weeks. Observe several record table, formulated with observed before and after treatment of TCM syndrome integral and related laboratory, and indexes variation statistical comparative analysis.Results: The total effective rate of the treatment group is 84.85% and control group total effectiveness is 70.00%, the curative effect of treatment group was better than control group (P<0.05). Two groups in improving joint swelling and pain, adverse, waist ache, shortness of breath, lazy to talk, fatigue, head heavy darkened, limbs heavy, dry mouth, night the symptom such as frequent micturition, which have apparent curative effect,and the curative effect of treatment group was better than control group (P<0.05). Two groups in, which improve renal function can obviously reduce cyanuric acid, blood urea nitrogen, lipid levels, including blood urea nitrogen, comparison between groups curative effect of treatment group was better than control group (P<0.05), blood uric acid, creatinine groups compared the non-significance difference (P>0.05). The treatment group urinary protein can significantly reduce theatients, than in control group (P<0.05). Both groups can effectively restrain yellow purine oxidase activity between groups, compared the non-significance difference (P>0.05). The treatment group can obviously lower urine N-acetyl-beta amino glycosidase enzymes were identified, urinary beta-half of lactose glucoside enzyme level, increase, better than the ratio between the control group (P<0.05).Conclusion: Shen kang jiag suan granules can effectively improve the uric acid sex nephrosis patient's clinical symptoms and signs. Exactly, safety and efficiency of side-effects,is the clinical effective drug treatment; Gouty nephropathy can obviously reduce patient blood urea nitrogen, uric acid, within, improve renal lipid levels so as to improve the microcirculation glomerular filtration function, and postpone renal impairment, and protect renal work; Can effectively reduce gouty renal patients, quantitative urinary protein microa lbuminuria, and reduce the urinary beta 2 micro globulin, reduce albuminuria, relieve renal damage; Can effectively restrain yellow purine oxidase activity, reducing blood uric acid; can reduce gouty nephropathy patients urine N-acetyl-beta amino glycosidase enzymes were identified, urinary beta - half of lactose glucoside enzyme level, increase the ratio between, thus effectively relieve renal interstitial injury prevention renal fibrosis.