The Clinical Observation On Effect Of The Square Reducing Uric Acid In Treating The Patients Of CKD 3-4 Accompany Hyperuricemia

Objective:On the basis of quality low-protein, low purine diet, alkaline urine, pressure control and lipid regulation, to observe the curative effect of JIANG-NIAO-SUAN-FANG treating the chronic kidney disease 3-4 phase with hyperuricemia, as well as the influence of serum uric acid changing to renal function, to discuss the treatment mechanism.Methods:Collect 56 qualified outpatients or hospitalized patients of Chinese medicinehospital in Jiangsu Province hospital from January 2009 to December 2010, and the number of patient in the treatment group or control group is 28. On the basis of low purine diet, alkaline urine, pressure control and lipid regulation, the period of the treatment group(n = 28) treated with JIANG-NIAO-SUAN-FANG and the control group(n=28) treated with routine Chinese medicinem is 8 weeks. The patients are observed on the change of serum uric acid(SUA), blood urea nitrogen(Bun), Creatinine(Scr) before and after treatment, meanwhile observed on the change of 24h urine protein with quantitative(U-TP), plasma albumin(Alb), total cholesterol(TC), triglycerides(TG) and adverse reaction.Results:1. Judge from the effect of hyperuricemia and renal function, the curative effect of treatment group is better than control group(P<0.05).2. The SUA level of patients in treatment group falls down significantly, with no obvious change in the control group, two groups of comparison has a statistical significance(P<0.05).3. In the treatment group, the Bun, Scr level of patients is down but eGFR level is up after treatment with no obvious change in the control group, and two therapeutic indexes(Scr, eGFR) change, two groups of comparison has a statistical significance(P<0.05).4. The U-TP level of patients in treatment group is down too after treatment, with no obvious change in the control group, two groups of comparison has a statistical significance(P<0.05); Hb, Alb, TC and TG of patients in two groups do not change obviously before and after treatment, two groups of comparison has no statistical significance(P>0.05).5. There is a positive correlation between SUA and renal function.Conclusions:1. JIANG-NIAO-SUAN-FANG can reduce the SUA level of patients who have the Chronic kidney disease(CKD) 3-4 phase with hyperuricemia.2. Reducing the SUA level is helpful for improving the renal funcion status of patients who have the Chronic kidney disease(CKD) 3-4 phase with hyperuricemia.