| Objective: Observes shenkangjiangsuan granules to the experimental uric acid nephrosis big mouse tubulus renalis mesenchymal TNF-α, IL-1βand TGF-β1 expression influence, the prevention function which to the uric acid objective evaluation shenkangjiangsuan granules causes the kidney which damages and discusses shenkangjiangsuan granules thoroughly the action mechanism.Methods: Divides into the blank group, the model group, the other purine mellow group, in stochastically the shenkangjiangsuan granules high monitoring team, shenkangjiangsuan granules 48 male Wistar big mice the monitoring team, the shenkangjiangsuan granules low monitoring team, fills stomach's method using the adenine + ethylamine butylacohol piece, the preparation uric acid nephrosis big mouse model.Results: Shenkangjiangsuan granules can reduce the blood uric acid, the blood myo- bitter wine, the blood urea nitrogen, the 24h urine protein quota, the urineβ2 microballoons protein, the blood fats obviously, and can decline effectively,TNF-α,IL-1βand TGF-β1 in the interrenal archery target expression.Conclusion: Shenkangjiangsuan granules can significantly reduce serum uric acid uric acid nephropathy in rats, reducing 24h urine protein and urineβ2 microglobulin; Shenkangjiangsuan granules reduce blood urea nitrogen, serum creatinine, to improve renal function; Shenkangjiangsuan granules improve lipid metabolism; Shenkangjiangsuan granules through reduced TNF-α, IL -1βand TGF-β1 expression in renal tissue, protecting renal function, delaying the process of renal interstitial fibrosis. |
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