The Research On The Clinical Relationship Between Intracranial Infection And Central Hyponatremia

Objective:To analyze the clinical features of central hyponatremia caused by intracranial infection and to investigate the mechanism about how intracranial infection results in central hyponatremia.Methods:To retrospectively analyze 36 patients hospitalized in neurosurgery ward of First Affiliated Hospital Of Dalian Medical Univer-sity between March 2009 and March 2010. These patients were diagnosed as intracranial infection with hyponatremia. To analyze the clinical features of central hyponatremia caused by intracranial infection through collecting the patients'data, such as the clinical symptoms, signs, laboratory examination, treatment, especially the level of protein and chloride in craniospinal fluids in the patients.Results:Of the 36 cases with intracranial infection with hyponatremia, 11 patients suffered from common hyponatremia(hypotonic dehydration), while the other 25 central hyponatremia,18 of whom were diagnosed as syndrome of inappropriate antidiuretic hormone (SIADH). The results of craniospinal fluid sample tests showed that the levels of protein in the craniospinal fluid from the 36 patients were all beyond the normal level, and the chloride of the 33 cases were lower than its normal limitation.Conclusion:1,The incidence of central hyponatremia is obviously higher than that of common hyponatremia in the cases of intracranial infec-tion with hyponatremia.2,The incidence of SIADH is obviously higher than that of cerebral salt-wasting syndrome in the cases of intracranial infection with central hyponatremia.3,The change of elements in craniospinal fluids, such as protein and chloride, may be one of the causes which lead into central hyponatremia.