| Objective:Analyze the composing experience of professor Yan Zhenghua for diseases by using Traditional Chinese Medicine (TCM) inheritance support system.Cellecting the prescriptions for diseases, then enter the data into TCM inheritance support system and analyze composing principles by using datamining methods such as revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster.Methods:Cellecting the prescriptions for Pulmonary Diseases, digestive system diseases, heart diseases, syndrome of qi stagnation, syndrome of blood stasis, arthralgia and most used of ten Chinese medicine, then enter the data into TCM inheritance support system and analyze the medication dose rule composing principles by using datamining methods such as revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster.Hope to provide reference for the inheritance, carry forward the academic thought of Professor Yan Zhenghua.Result:Professor Yan prescription drugs that are used in property of warm (7998 times), followed by the property of cool (7866 times), property of leveling (6763 times), property of cold (3942 times), property of hot (95 times), the use of drugs bitterness up (15260 times), followed by Sweet (10810 times), pungent (10,453 times), sour (2794 times), salty (1651 times), Mild (1203 times), astringency (186 times).The commonly used doses of the high-frequency drugs in these prescriptions are:red paeonia (15g), dried orangepeel (10g), salvia (20g), tuckahoe, paenoiae alba (15g), parched semen ziziphi spinosae (30g), vine of multiflower knotweed (30g), chiretta (6g), which are in line with the dose range that Chinese Pharmacopoeia provided.In treatment of pulmonary diseases by Prof. YAN Zhen-hua there were 15 herbs with a higher use frequency of over 89 times,19 commonly-used herb pairs with a higher use frequency of over 115times,16 commonly-used herb core combinations with Confidence of over 0.98 and support level over 20% were achieved with the modified mutual information method.In treatment of digestive system diseases by Prof. YAN Zhen-hua,the highest frequency used drugs were Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Platycodonis, Radix Asteris, and so on. The most frequency drug combinations were "Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum", "Radix Glycyrrhizae, Bulbus Fritillariae Thunbergii", "Radix Glycyrrhizae, Radix Platycodonis", "Radix Platycodonis, Bulbus Fritillariae Thunbergii". The drug association rules that the confidence was more than 0.9 were "Radix Glycyrrhizae, Rhizoma Cynanchi Stauntonii-> Radix Stemonae", "Rhizoma Cynanchi Stauntonii,Radix Scutellariae-> Radix Stemonae", "Radix Glycyrrhizae, Rhizoma Cynanchi Stauntonii, Bulbus Fritillariae Thunbergii-> Radix Stemonae"and "Radix Glycyrrhizae, Rhizoma Cynanchi Stauntonii, Semen Armeniacae Amarum-> Radix Stemonae, and so on.Based on the analysis of 305 Prescriptions, the highest frequency used drugs were RadixSalviae Miltiorrhizae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Concha Ostreae, Poria, and so on. The most frequency drug combinations were "Concha Ostreae, Os Draconis", "Caulis Polygoni Multiflori, Semen Ziziphi Spinosae", and "Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae". The drug association rules that the confidence was more than 0.9 were "Lignum Dalbergiae Odoriferae-> Radix Salviae Miltiorrhizae", "Bulbus Allii Macrostemonis-> Semen Ziziphi Spinosae", "Os Draconis->Concha Ostreae", and "Radix Salviae Miltiorrhizae, Os Draconis-> Concha Ostreae", and so on.Based on the analysis of 255 syndrome of stagnation of QI Prescriptions, the highest frequency used drugs were Pericarpium Citri Reticulatae, Rhizoma Cyperi, Radix Paeoniae Rubra, Radix Paeoniae Alba, Fructus Citri Sarcodactylis, and so on. The most frequency drug combinations were "Pericarpium Citri Reticulatae, Rhizoma Cyperi", "Radix Paeoniae Rubra, Rhizoma Cyperi", and "Radix Paeoniae Rubra, Pericarpium Citri Reticulatae". The drug association rules that the confidence was more than 0.9 were "Radix Paeoniae Rubra,Pericarpium Citri Reticulatae Viride-> Pericarpium Citri Reticulatae", "Radix Paeoniae Rubra,Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi-> Pericarpium Citri Reticulatae", "Radix Paeoniae Rubra,Pericarpium Citri Reticulatae Viride, Radix Bupleuri-> Pericarpium Citri Reticulatae", and "Radix Paeoniae Alba, Radix Paeoniae Rubra, Pericarpium Citri Reticulatae Viride-> Pericarpium Citri Reticulatae", and so on.Based on the analysis of 114 syndrome of blood stasis Prescriptions, the highest frequency used drugs were Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae, Rhizoma Ligustici Chuanxiong, Flowers Carthami, Radix Angelicae Sinensis, and so on. The most frequency drug combinations were "Rhizoma Ligustici Chuanxiong, Radix Paeoniae Rubra", "Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra", and "Rhizoma Ligustici Chuanxiong, Radix Salviae Miltiorrhizae". The drug association rules that the confidence was more than 0.9 were "Lignum Dalbergiae Odoriferae-> Radix Salviae Miltiorrhizae", "Rhizoma Ligustici Chuanxiong,Lignum Dalbergiae Odoriferae-> Radix Salviae Miltiorrhizae", "Radix Paeoniae Rubra,Lignum Dalbergiae Odoriferae-> Radix Salviae Miltiorrhizae", and "Radix Angelicae Sinensis, Flowers Carthami-> Radix Paeoniae Rubra", and so on.Based on the analysis of 102 arthralgia syndrome Prescriptions, the highest frequency used drugs were Radix Paeoniae Rubra, Herba Taxilli, Ramulus Mori, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, and so on. The most frequency drug combinations were "Ramulus Mori, Herba Taxilli", "Radix Paeoniae Rubra, Ramulus Mori", and "Radix Paeoniae Rubra, Herba Taxilli". The drug association rules that the confidence was more than 0.9 were "Radix Achyranthis Bidentatae-> Ramulus Mori, Herba Taxilli", "Radix Saposhnikoviae, Herba Taxilli-> Ramulus Mori", "Radix Paeoniae Rubra,-> Radix Clematidis,Radix Gentianae Macrophyllae", and "Radix Clematidis-> Ramulus Mori,Herba Taxilli", and so on.The prescriptions including Radix Paeoniae Rubra were commonly used to treat vertigo, stomach-ache, arthralgia and other syndromes. The highest frequency used drugs were Cortex Moutan Radicis, Radix Paeoniae Alba, Pericarpium Citri Reticulatae and so on. The most frequency drug combinations were "Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra", "Radix Paeoniae Alba, Radix Paeoniae Rubra", and "Radix Paeoniae Rubra, Pericarpium Citri Reticulatae". The drug association rules that the confidence was more than 1 were "Radix Glycyrrhizae-> Radix Paeoniae Rubra", "Cortex Moutan Radicis,-> Radix Paeoniae Rubra", "Radix Achyranthis Bidentatae-> Radix Paeoniae Rubra", and "Radix Paeoniae Alba-> Radix Paeoniae Rubra", and so on.The prescriptions including Pericarpium Citri Reticulatae were commonly used to treat stomach-ache, cough, acid regurgitation and other syndromes. The highest frequency used drugs were Poria,, Radix Paeoniae Rubra, Rhizoma Cyperi, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae and so on. The most frequency drug combinations were "Pericarpium Citri Reticulatae, Poria", "Radix Paeoniae Rubra, Pericarpium Citri Reticulatae", and "Pericarpium Citri Reticulatae, Rhizoma Cyperi". The drug association rules that the confidence was more than 0.9 were "Radix Glycyrrhizae-> Pericarpium Citri Reticulatae", "Radix Paeoniae Alba,-> Pericarpium Citri Reticulatae", "Radix Angelicae Sinensis-> Pericarpium Citri Reticulatae", and "Poria-> Pericarpium Citri Reticulatae", and so on.The prescriptions including Radix Salviae Miltiorrhizae were commonly used to treat vertigo, chest discomfort, insomnia and other syndromes. The highest frequency used drugs were Radix Paeoniae Rubra, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Paeoniae Alba, Poria,and so on. The most frequency drug combinations were "Radix Salviae Miltiorrhizae, poria", "Radix Salviae Miltiorrhizae, poria", and "Radix Salviae Miltiorrhizae, Parched Semen Ziziphi Spinosae". The drug association rules that the confidence was more than 1 were "Radix Achyranthis Bidentatae-> Radix Salviae Miltiorrhizae", "Radix Paeoniae Alba-> Radix Salviae Miltiorrhizae", "Radix Paeoniae Rubra-> Radix Salviae Miltiorrhizae". and "Concha Ostreae-> Radix Salviae Miltiorrhizae", and so on.The prescriptions including poria were commonly used to treat megrim, stomach-ache, diarrhoea and other syndromes. The highest frequency used drugs were Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Parched Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, and so on. The most frequency drug combinations were "Pericarpium Citri Reticulatae, poria", "Radix Salviae Miltiorrhizae, poria", and "poria, Parched Semen Ziziphi Spinosae". The drug association rules that the confidence was more than 0.9 were "Carina-> Oyster", "poria, Carina-> Oyster", "Oyster, Caulis Polygoni Multiflori-> Carina", and "Rhizoma Atractylodis Macrocephalae-> poria", and so on.The prescriptions including Radices Paeoniae Alba were commonly used to treat megrim, stomach-ache, acid regurgitation and other syndromes. The highest frequency used drugs were Radix Paeoniae Rubra, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Poria, and so on. The most frequency drug combinations were "Radices paeoniae alba, Radix Paeoniae Rubra", "Radix Salviae Miltiorrhizae, Radices paeoniae alba", and "Radices paeoniae alba, Pericarpium Citri Reticulatae". The drug association rules that the confidence was more than 0.9 were "Radix Paeoniae Rubra-> Radices paeoniae alba", "Os Draconis-> Concha Ostreae", "Radix Angelicae Sinensis,Radix Paeoniae Rubra-> Radices paeoniae alba", and "Radix Paeoniae Rubra, Herba Taxilli-> Radices paeoniae alba", and so on.The prescriptions including Fried Semen Ziziphi Spinosae were commonly used to treat insomnia, megrim, thoracic obstruction and other syndromes. The highest frequency used drugs were Caulis Polygoni Multiflori, Concha Ostreae.Os Draconis,Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, and so on. The most frequency drug combinations were "Caulis Polygoni Multiflori, Fried Semen Ziziphi Spinosae", "Concha Ostreae, Fried Semen Ziziphi Spinosae", and "Os Draconis, Fried Semen Ziziphi Spinosae". The drug association rules that the confidence was more than 0.9 were "Poria-> Fried Semen Ziziphi Spinosae", "Pericarpium Citri Reticulatae-> Fried Semen Ziziphi Spinosae","Caulis Polygoni Multiflori-> Fried Semen Ziziphi Spinosae", and "Radix Paeoniae Alba-> Fried Semen Ziziphi Spinosae", and so on.The prescriptions including Radix Angelicae Sinensis were commonly used to treat stomach-ache, arthralgia syndrome, irregular menstruation and other syndromes. The highest frequency used drugs were Radix Paeoniae Rubra, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, and so on. The most frequency drug combinations were "Radix Angelicae Sinensis, Radix Paeoniae Rubra", "Radix Paeoniae Alba, Radix Angelicae Sinensis", and "Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis". The drug association rules that the confidence was more than 0.9 were "Fructus Jujubae-> Radix Angelicae Sinensis", "Fructus Amomi Villosi-> Radix Angelicae Sinensis", "Radix Codonopsis->Radix Angelicae Sinensis", and "Os Draconis-> Concha Ostreae", and so on.The prescriptions including Concha ostreae were commonly used to treat insomnia, vertigo, stomach-ache and other syndromes. The highest frequency used drugs were Os Draconis, Fired Semen Zizyphi Spinosae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, and so on. The most frequency drug combinations were "Concha Ostreae, Os Draconis", "Concha Ostreae, Fired Semen Zizyphi Spinosae", and "Concha Ostreae, Caulis Polygoni Multiflori". The drug association rules that the confidence was more than 0.9 were "Os Draconis->Concha Ostreae","Poria,Os Draconis->Concha Ostreae", "Os Draconis, Fired Semen Zizyphi Spinosae-> Concha Ostreae", and "Radix Salviae Miltiorrhizae,Os Draconis->Concha Ostreae", and so on.The prescriptions including Caulis polygoni multiflori were commonly used to treat insomnia, vertigo, chest discomfort and other syndromes. The highest frequency used drugs were Fired Semen Ziziphi Spinosae, Concha Ostreae, Os Draconis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, and so on. The most frequency drug combinations were "Caulis polygoni multiflori, Fired Semen Ziziphi Spinosae", "Concha Ostreae, Concha Ostreae", and "Concha Ostreae, Os Draconis". The drug association rules that the confidence was more than 0.9 were "Pericarpium Citri Reticulatae->Caulis polygoni multiflori", "Poria->Caulis polygoni multiflori", "Fired Semen Ziziphi Spinosae->Caulis polygoni multiflori", and "Radix Paeoniae Alba->Caulis polygoni multiflori", and so on.The prescriptions including Rhizoma Cyperi were commonly used to treat stomach-ache,sour regurgitation, hypochondriac pain and other syndromes. The highest frequency used drugs were Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Radix Paeoniae Alba,Radix Salviae Miltiorrhizae, Fructus Citri Sarcodactylis, and so on. The most frequency drug combinations were "Pericarpium Citri Reticulatae,Rhizoma Cyperi", "Radix Paeoniae Rubra,Rhizoma Cyperi", and "Radix Paeoniae Alba,Rhizoma Cyperi". The drug association rules that the confidence was more than 0.9 were "Os Draconis->Concha Ostreae". "Rhizoma Cyperi, Os Draconis->Concha Ostreae", "Radix Paeoniae Rubra, Radix Bupleuri-> Rhizoma Cyperi",and"Pericarpium Citri Reticulatae Viride->Rhizoma Cyperi", and so on.Conclusion:Professor Yan Zhenghua medication which to cool based medicine, Sweet, pungent drugs mostly, strictly grasp four five flavors of drug laws, each being at peace to take effect, cross-checks and treatment, known every medicine use, flexible and have experience.The clinical experience of Dr. Yan Zhenghua is seasoned, he used the medicine with a small dose, which can be get good effect.The results attained with data mining technique for studying experience of famous and old TCM physicians conform to the clinical practice and the method is of an important significance for summarization of famous and old TCM physicians’experiences.Professor Yan Zhenghua is good at conditioning the blood vessel operation and tranquilizing by nourishing the heart, TCM inheritance support system can be used to analyze old TCM doctor’clinical experience.Professor Yan Zhenghua is good at soothing the liver and regulating qi to relieve acheProfessor Yan Zhenghua is good at activating blood circulation to dissipate blood stasis and regulating qi to relieve ache.Professor Yan Zhenghua is good at tonifying kidney and eliminating dampness, promoting blood circulation and removing blood stasisThe drugs in Radix Paeoniae Rubra prescription that built by Pro. Yan mostly had the effects of multi-qi and blood circulation of the efficacy of drug concentration,The drugs in Pericarpium Citri Reticulatae prescription that built by Pro. Yan mostly had the effects of multi effect with qi and blood circulation,Professor Yan Zhenghua containing radix salviae miltiorrhizae prescription drugs used more with blood circulation, soothe the nerves of the efficacy of medication is more concentrated, The drugs in the prescriptions containing Poria that built by Pro. Yan mostly had the effects of regulating the flow of qi, relieving uneasiness of body and mind, and cooling the blood, The drugs in the prescriptions containing Radices paeoniae alba that built by Pro. Yan mostly had the effects of enriching the blood and invigorating the circulation of blood, relieve uneasiness of mind and body tranquilization,The drugs in the prescriptions containing Fried Semen Ziziphi Spinosae that built by Pro. Yan mostly had the effects of enriching the blood, invigorating the circulation of blood, and relieving uneasiness of mind and body tranquilization,The drugs in the prescriptions containing Radix Angelicae Sinensis that built by Pro. Yan mostly had the effects of cooling blood, replenishing blood, and promoting blood circulation for removing blood stasis,The drugs in the prescriptions containing Concha Ostreae that built by Pro. Yan mostly had the effects of replenishing blood, relieving uneasiness of mind and body tranquilization, and activating blood circulation to dissipate blood stasis,The drugs in the prescriptions containing Caulis polygoni multiflori that built by Pro. Yan mostly had the effects of relieving uneasiness of mind and body tranquilization, replenishing blood, and invigorating the circulation of blood.The drugs in the prescriptions containing Rhizoma Cyperi that built by Pro. Yan mostly had the effects of regulating the flow of vital energy and remove obstruction toit, replenishing blood, and promoting blood circulation for removing blood stasis... |
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