A Researeh On The Relationship Between The Body Constitution Type In TCM And Clinical Syndromes And Receptor ER, PR And Her-2of The Breast Cancer

Objective:Breast cancer one of the most common malignancy in women, the incidence of the more accounted for7%to10%of the systemic variety of malignant tumors. The higher incidence of premenopausal and postmenopausal women [1]. Preliminary study of breast distribution pattern of breast cancer with traditional Chinese medicine constitution and syndromes type receptor (ER, PR, HER-2three receptor positive or negative) Survey Research, Taiwan Province, a few hospitals in female patients the prevalence of cancer TCM constitution and syndromes type distribution characteristics; proven breast cancer physique receptor status.Methods:This study is effective to obtain the object of the scope of research for this study, and therefore take the convenience sampling this. But outpatient and inpatient clinical diagnosis of cancer Society of Friends for patients with breast cancer issue questionnaire, and patients on the spot to recover the information collected by the outpatient and inpatient cancer Friends of professional physicians responsible, relevant information is entered and stored in the examination center computer systems. Collection cases for a total of100cases, the use of epidemiological case analysis.Using count data by the chi-square test, P>0.05, and prompted no significant difference comparable. SPSS17.0statistical software, statistical methods of count data rank sum test, chi-square test, and logistic regression analysis of multivariate data. Results:1,Distribution of TCM constitution of Taiwan,100breast cancer patients in order from largest to smallest:qi quality (20%), yin deficiency (16%) the yang quality (15%), Qi deficiency (14%), blood stasisquality (12%), peace and quality (10%), phlegm (5%), hot and humid quality (4%), special intrinsic quality.No significant correlation (P<0.05) between the constitution and age, hormone receptor expression.2, Taiwan,100patients with breast cancer TCM type distribution in order from largest to smallest:98cases, the liver depression Tanning type35cases,35%; Chong and Ren disorders type for52cases (52%);positive imaginary poison Chi type13cases (13%); dialectical two cases can not be accounted for2%. The difference was statistically significant between Syndromes and pathological staging. Taiwan receptor ER, PR and Her-2receptor expression in breast cancer patients with TCM constitution were statistically analyzed100patients, immunohistochemical examination of nine cases, the remaining91patientstypes of constitutions and ER, PR receptor expression statistical analysis, P>0.05, prompted the various physical types and ER, PR receptor was no statistically significant difference. Types of constitutions and the Her-2receptor expression statistical analysis of the results showed no significant correlation between elements of the Her-2positive expression rate of breast cancer evidence-type constitution, Yang and Qi Deficiency physical elements patients with Her-2positive expression rate, suggesting that should Yiqiwenyang drugs can improve the prognosis of patients.4, Taiwan breast TCM Syndrome type receptor ER, PR, Her-2receptor expression were analyzed statistically, the liver depression Tanning positive rate and positive imaginary poison Chi comparison, and the difference was not statisticallysignificant (P=0.074); liver depression Tanning ER-positive rate and Chong and Ren disorders, and the difference was statistically significant (P=0.022). Syndromes PR, Her-2positive rate comparison, and the difference was not significant. Early breast cancer is liver depression the Tanning-type, late positive imaginary poison Chi type. Liver depression the Tanning-type expression levels higher than Chong and Ren disorders and PR, Her-2’s expression TCM type had no significant correlation.5, the distribution of triple negative breast cancer patients in Taiwan TCM constitution:peaceful quality, four cases of qi deficiency, yang quality, yin deficiency, blood stasis quality two cases, three cases of phlegm, hot and humid and qualityl case, qi quality six cases, two cases of special intrinsic quality.6Taiwan triple negative breast cancer patients TCM type in the early, mid-the liver depression Tanning card and Chong and Ren disorders card mainly positive imaginary poison Chi certificate in advanced; Chong and Ren lost cards and poor prognosis organizationhistological type is higher than the other syndromes; positive imaginary poison Chi certificate clinicopathological parameters of poor prognosis than other patterns, suggesting that the positive imaginary poison Chi permit patients with severe illness, the prognosis may be better than the other syndromes, three sets of card typeprognosis by long-term follow-up in order to determine the patient.Conclusions:In this paper, a survey questionnaire of100cases of breast cancer patients in Taiwan, preliminary study of the prevalence of breast cancer TCM constitution and syndromes type distribution characteristics; proven breast cancer physique and card type receptor (ER, PR, Her-2) case correlation. In this study, the following conclusions:1. Taiwan physical distribution of breast cancer patients with TCM concentrated in the qi quality, yin deficiency, yang quality, Qi deficiency, blood stasis quality.2. Taiwan TCM type of breast cancer patients focused on the distribution of red of any imbalance cards and liver depression Tanning card.3. TCM constitution of the breast cancer patients in Taiwan with the receptor ER, PR receptor expression were analyzed statistically, P>0.05, prompt physical type of ER, PR receptor was no statistically significant difference.Types of constitutions and the Her-2 receptor expression statistical analysis of the results showed no significant correlation between elements of the Her-2positive expression rate of breast cancer evidence-type constitution, Yang and Qi Deficiency physical elementspatients with Her-2positive expression rate, the tips should be Yiqiwenyang drugs can improve the prognosis of patients.4. Taiwan breast TCM Syndrome Type and receptor ER, PR receptor expression were analyzed statistically, P>0.05, no significant statistical difference prompted. Syndromes and Her-2, Chong and Ren disorders permit the Her-2protein expression was significantly higher than the other two groups, statistical analysis, there are significant differences.5. Taiwan triple negative breast cancer patients TCM constitution centralized distribution qi quality, yin deficiency, yang quality, qi deficiency, blood stasis quality, phlegm.6. Taiwan triple negative breast cancer patients TCM type distribution is concentrated in the early and mid-term disorders card the liver depression Tanning card and Chong and Ren mainly in the late positive imaginary poison Chi certificate.