Study On The Related Factors And TCM Syndrome Distribution Of T2DM Combined With Osteoporosi

Purpose:To observe the clinical symptoms and TCM Syndromes of type Diabetes diabetes mellitus combined with osteoporosis(Osteopenia DOP),and to retrospectively analyze the data.According to the relevant diagnostic criteria,the correlation factors of type 2 diabetes with osteoporosis,the distribution of TCM syndromes,the relationship between TCM syndromes and the related factors were analyzed and discussed.To provide a theoretical basis for the prevention and treatment of type 2 diabetes mellitus with osteoporosis.Material and method:a total of 165 patients with type 2 diabetes were selected from Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 2020 to September 2021.According to the inclusion criteria and exclusion criteria,165 cases were collected and divided into 62 groups(group T2DM)with normal bone mass,50 cases with osteopenia(group R),and 53 cases of osteoporosis group(group DOP).Collect the general information(gender,age,course of disease,smoking history,drinking history,complications,TCM syndrome types,etc.)and laboratory indicators(blood glucose,C-peptide,triglyceride,total cholesterol,blood magnesium,blood calcium,etc.)of the three groups,analyze the differences of clinical data of the three groups,and compare the differences of gender and related indicators between T2 DM group and DOP group,Logistic regression analysis was used to analyze the related factors of type 2 diabetes mellitus with osteoporosis.The distribution characteristics of TCM Syndrome Types and the correlation between TCM Syndromes of DOP group and various factors were observed in the three groups.Results:1.there was a significant difference in smoking history,drinking history,female menopausal ratio,duration of diabetes,BMI and WC between the three groups(P < 0.05),but there was no significant difference in gender,family history,age,DM diagnostic age,SBP,DBP and menopause age(P > 0.05).After pairwise comparison,compared with T2 DM group,DOP group had a larger proportion of drinking history and a longer course of disease,while the levels of BMI and WC were lower.(P<0.05)。2.There were significant differences in Hb A1 c,TG,TC,HDL-C,Mg,HGB,MHR,combined DPN and DKD among the three groups(P < 0.05),but there was no significant difference in liver and kidney function indexes,lym,NE,FT3 and FT4(P > 0.05).Compared with T2 DM group,the level of Hb A1 c in DOP group was higher,while the levels of TG,Mg and HGB were lower.The complication of DOP group was mainly DKD(P < 0.05).3.In female patients,compared with T2 DM group,the course of disease in DOP group was longer and TG,TC and Mg were lower(P < 0.05),Male DOP patients had higher WC level(P < 0.05),The BMI level of DOP patients was low(P < 0.05),which was not affected by gender.4.According to the results of logistic regression analysis,drinking history,the proportion of female menopause and DKD were the independent risk factors of DOP,WC and Mg were independent protective factors of DOP(P < 0.05).5.Distribution of TCM syndrome types of DOP: mainly liver and kidney deficiency syndrome,followed by Qi and yin deficiency syndrome,dampness and heat trapping spleen syndrome,yin deficiency and fire hyperactivity syndrome,yin and yang deficiency syndrome,and the main concurrent syndrome is blood stasis blocking collaterals syndrome.The clinical data of each TCM syndrome type were analyzed by one-way ANOVA,and there were statistical differences in the following two aspects:(1)age: liver and kidney deficiency syndrome > Yin deficiency and fire syndrome(P = 0.005),yin and yang deficiency syndrome > Yin deficiency and fire syndrome(P = 0.001),(2)blood magnesium: Qi and yin deficiency syndrome < Yin deficiency and fire syndrome(P < 0.001),liver and kidney deficiency syndrome < Yin deficiency and fire syndrome(P = 0.004)Conclusion:1.Compared with T2 DM group,the smoking history and MHR level of Group R were higher,while the levels of TC and HDL-C were lower,and the main complication was DPN;The drinking history,course of disease and Hb A1 c level in DOP group were higher,while the levels of BMI,WC,TG,Mg and HGB were lower.The main complication was DKD;2.Drinking history,female menopause and DKD were independent risk factors for DOP,while WC and Mg were independent protective factors for DOP;3.Among DOP patients,female patients have a longer course of disease,lower levels of TG,TC and Mg,higher levels of WC in male patients and lower BMI in DOP patients,which is independent of gender;4.The syndrome type of DOP is mainly liver and kidney deficiency syndrome,and the syndrome of blood stasis blocking collaterals is more common;5.There are significant differences in age and blood magnesium indexes among TCM syndrome types of DOP patients.The age of patients with liver and kidney deficiency syndrome and yin-yang deficiency syndrome is higher.The blood magnesium level of patients with liver and kidney deficiency syndrome and Qi and yin deficiency syndrome is low.