| Objective(s): Objective To investigate the effects of artificial bone repair materials and hydroxyapatite bioceramics on the repair of bone defects and to evaluate the effectiveness and safety of artificial bone repair materials.Methods: A total of 50 patients with bone defects treated in the 920 Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army from December2019 to April 2021 were randomly divided into new artificial bone repair group(n=25)and hydroxyapatite bioceramic group(n=25).(The artificial bone repair materials developed by Wuhan Asia Biomaterials Co.,LTD.,mainly composed of hydroxyapatite,chemical formula: Ca10(PO4)6(OH)2.)Product appearance shape:granular,strip,cylindrical or block;It can be made into special shape and size according to the needs of different parts),hydroxyapatite bioceramics group(control group)(Hydroxyapatite bioceramics produced by biomaterials Engineering Research Center of Sichuan University [National Instrument Registration 20173460346].Reasons for selection of reference products: The bone repair mechanism is the same,this product has been marketed in China,is the most representative of similar products;A large number of clinical applications and data have proven the safety and effectiveness of this product)The bone graft fusion rates of the two groups were observed and compared at 1 week,6 weeks,12 weeks and 24 weeks after operation.and the changes of blood routine,neutrophil percentage,C-reactive protein,ESR,creatinine,glutamic pyruvic transaminase and glutamic oxaloacetic transaminase before and 1 week after operation were recorded.Results: After operation,the vital signs of 46 patients were stable,the incisions healed in the first stage,and no adverse events occurred.There was no significant difference in the number of bone graft fusion between the two groups at 1week,6 weeks,12 weeks and 24 weeks after operation,but the white blood cell count(WBC)and the percentage of neutrophils(NEU)increased significantly between the two groups,especially in the hydroxyapatite biological ceramic group.There was no significant difference in the results of glutamic pyruvic transaminase(ALT)and aspartate oxaloacetic transaminase(AST)between the two groups,and the serum creatinine in the experimental group decreased significantly after operation,but there was no significant difference between the two groups.Conclusion(s): The new artificial bone repair materials and hydroxyapatite bioceramics showed good clinical effect in the repair of bone defect of four limbs.Therefore,the new artificial bone repair materials can be used as a good substitute for hydroxyapatite bioceramics in the treatment of limb bone defects. |
