Effects Of Two Modes Of Noninvasive Ventilation On Bronchopulmonary Dysplasia In Preterm Infants

Objective(s):1.To compare the use of nasal continuous positive pressure ventilation(NCPAP)and biphasic positive pressure ventilation(Bi-PAP)with the incidence and mortality of bronchopulmonary dysplasia(BPD)in preterm infants;2.To explore the risk factors for bronchopulmonary dysplasia(BPD).Method(s): Premature infants with gestational age ≤32 weeks admitted to the neonatology department of our hospital within 24 hours after birth from the beginning of January 2019 to the end of December 2022 were divided into two groups,nasal continuous positive pressure ventilation(NCPAP)and biphasic positive pressure ventilation(Bi-PAP),according to the different initial ventilation methods,and the basic clinical data of the children and the incidence of BPD,mortality rate,intubation rate,related complications,length of hospital stay,hospitalization cost and other data were statistically analyzed and compared;The risk factors for the incidence of BPD in our hospital were statistically calculated through logistic regression analysis.Result(s): 1.A total of 102 preterm infants were included in the study,including 35 children in the NCPAP group and 67 children in the Bi-PAP group,and the incidence and mortality rate of BPD in children using Bi-PAP were higher than those in NCPAP(14.3% vs 11.9%,8.6% vs.1.5%),but the difference was not statistically significant(P=0.761,P=0.116);The P value of patent ductus arteriosus(PDA),neonatal retinopathy(ROP),intraventricular hemorrhage(IVH),and neonatal necrotizing enterocolitis(NEC)was greater than 0.05(P=0.213,P=0.377,P=1.000,P=1.000),which was not statistically significant;There were no significant differences in reintubation rate,length of hospital stay and hospital cost(P=0.402,P=0.977,P=0.472).2.Gestational age,birth weight,sex,duration of oxygen intake,and duration of ventilator use were risk factors for the development of BPD,among which duration of oxygen inhalation was an independent risk factor for the development of BPD.Conclusion(s): 1.There was no significant difference in the incidence and mortality rate of BPD in preterm infants using non-invasive ventilation between the two groups;There were no significant differences in related complications,reintubation rate,length of hospital stay,and hospitalization costs.2.Gestational age,birth weight,gender,oxygen inhalation time,and ventilator use time are risk factors for the incidence of BPD,among which oxygen inhalation time is an independent risk factor for the incidence of BPD.