Clincal Analysis Of Bronchopulmonary Dysplasia In Premature Infants And Its Relationship With Ureaplasma Urealyicum Infection

Objective:To explore the high-risk factors,clinical characteristics and treatment of bronchopulmonary dysplasia(BPD),and to explore the clinical characteristics of ureaplasma urealyicum (UU), in order to offer advices for the prevention and treatment of BPD, and to improve the quality of life of premature infants, and to reduce the occurrence of adverse prognosis.Methods:1.229preterm infants with gestational aged less than34weeks were enrolled in the study, from January1st2007to August312011.According to the presence or absence of bronchopulmonary dysplasia (BPD) were divided into2groups, two groups of data were analyzed by using statistical analysis.2.85preterm infants with gestational age less than35weeks, from Septemberlst2010to August312011,who had low respiratory tract secretion tested for ureaplasma urealyicum DNA by the polymerasw chain reaction. According to UU-DNA assay results for infection group and the non infection group, analyzed two groups data by using statistical analysis.Results:1. Among229premature infants133(58.1%) were male and96(41.9%) were female.Average gestational age at discharge were32.3+1.5w. Average weight at discharge were1760.8+365.8g. The prevalence of BPD was15.7%,13mild cases (36.1%),21moderate case(58.3%),2severe case(5.6%).Less than28w1cases(100%)s between28w and30w12cases(63.2%),between30w and32w10cases(20.8%), between32w and34w13cases(8%). Disposition of birth weight:less than1500g18cases(34.6%,between1500g and2000g15cases(12.8%),more than2000g3cases(5%).30patients requiring mechanical ventilation treatment,in which BPD occur in19patients (63.3%).The average time of inhaling oxygen were19±18days,the average time of mechanical ventilation were8.3±10.2days,average time stay hospita were27.7±18.5days,average weight of leave hosptial were2248.8±390.3g.2. The single factor analysis demonstrated that the BPD high-risk factors were gestational age, birth weight, very low birth weight infants, asphyxia, RDS, neonatal pneumonia, sepsis, ventilator-associated pneumonia, IDM, use PS, Intravenous use hormone, PH value, antibiotics use time,time inhaling oxygen, Fio2≥0.4, use NCPAP, mechanical ventilation, count of white cell.3. Multivariate logistic analysis revealed that gestational age, IDM, mechanical ventilation, Fio2≥0.4, NCPAP use were related with BPD.,4. At14days after birth weight and head circumference were statistically significant. But in the corrected gestational age of36weeks, weight, length, head circumference showed no significant differences.5. Two weeks after brith protein and calorie intake had statisticly difference in infants of two groups6. The incidence of UU was16.5%.7. The incidence of BPD in UU positive group was21.4%.8. UU Positive group had higher incidence of premature rapture of membranes, Sponianeous vaginal delivery,and Neonatal pneumonia.Conclusion:1.The risk factors of BPD were gestational age, mechanical ventilation, Fio2≥0.4, inhaling oxygen, so these risk factors should be actively prevented,in order to reduce the occurrence of BPD.2. Premature intake fewer calories and protein quality maybe one of the risk factors of BPD.3.Ureaplasma urealyticum may be one of the pathogens related to BPD,.we should pay attention to it.