| Background: Microvascular invasion(MVI)is an important predictor of postoperative recurrence risk of liver cancer.Preoperative identification of MVI is helpful for accurate treatment of hepatocellular carcinoma.However,the sensitivity and specificity of MVI predictive indicators involved in current studies still do not meet clinical requirements.Objective: The purpose of this study was to investigate the diagnostic value of peripheral blood circulating tumor cells(CTCs)in preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma.Methods: A total of 121 patients with hepatocellular carcinoma who received radical surgical resection in the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Guangzhou Medical University from March 2021 to March 23 were retrospectively analyzed.The following clinicopathologic data were collected,including age,sex,hepatitis B virus surface antigen(HBs Ag),cirrhosis,Child-Pugh grade,tumor number,tumor size,serum AFP level,serum abnormal prothrombin(DCP)level,preoperative CTCs detection and postoperative pathological MVI results.According to postoperative pathological MVI expression,patients were divided into MVI positive group and MVI negative group.The correlation between CTCs,clinicopathological features and MVI was analyzed,and the ROC curve was used to evaluate the ability of CTCs to predict MVI before surgery.Results: The ability to predict the occurrence of MVI was most significant when the preoperative CTCs were ≥3 /5m L [OR=16.223,95%CI(4.854-54.224),P <0.001].In multivariate analysis,preoperative CTCs count ≥3 /5m L,AFP level ≥400μg/L,DCP level ≥40m AU/m L,tumor size ≥5cm and multiple tumors were independent risk factors for MVI(P < 0.05).Multi-factor combined prediction of MVI has better efficiency.Conclusion: Preoperative peripheral blood CTCs ≥3 /5m L in HCC patients is closely related to the occurrence of MVI.Preoperative CTCs ≥3 /5m L can better predict the occurrence of MVI. |
