Relationship Between Preoperative CT Imaging Features And Prognosis Of Stage Ⅰ Non-small Cell Lung Cancer

Objective: TO Exploring the relationship between preoperative CT imaging features and prognosis of clinical stage I non-small cell lung cancer。Methods: Imaging and postoperative pathology data were collected from 417 patients with non-small cell lung cancer who had complete preoperative enhanced CT examination images and postoperative pathology consistent with clinical stage I at the Fourth Hospital of Hebei Medical University between January 2016 and December 2017.Follow-up was performed using review of case data and telephone callbacks,with the start date of follow-up being the date of surgery and the cut-off date being July 2022.Patients’ age(≤60 years/>60 years),gender(male/female),tumor location,tumor type(central type lung cancer/peripheral type lung cancer),tumor density(solid/partially solid/pure ground glass),tumor margin characteristics(lobar sign/burr sign/pleural depression sign),structural relationship between peritumoral veins and tumor,and peritumoral vein diameter(diameter ≤3.05 mm/diameter >3.05 mm)were analyzed and collected and combined with their 5-year disease-free survival(DFS)to assess the prognosis of the patients.The data in this study were processed and analyzed using SPSS 26.0 software,and the Kaplan-Meier curve and multifactorial COX proportional risk model were used for survival analysis,and P<0.05 was considered a statistically significant difference.X。Results: A total of 417 patients with clinical stage I non-small cell lung cancer were included in this study,with a median follow-up time of 59 months(interquartile distance,56-64 months),48 cases of recurrent metastasis or death during the follow-up time,and 369 cases of disease-free survival,with a cumulative disease-free survival rate of 88.5%.The results of univariate analysis showed that tumor stage,tumor location,tumor type,tumor density,pleural depression sign,burr sign,structural relationship between peritumoral vein and tumor,and peritumoral vein diameter were associated with patients’ prognosis of disease-free survival(P<0.05).Further,the above 8 factors were included in a multifactorial COX proportional risk model for survival analysis,and the results showed that 5 factors,including tumor stage,tumor location,pleural depression sign,structural relationship between perineural vein and tumor,and perineural vein diameter,were associated with 5-year disease-free survival after surgery in patients with stage I non-small cell lung cancer(P<0.05).Conclusions: This study elucidated five factors,including tumor stage,tumor location,pleural depression sign,structural relationship between peritumoral vein and tumor,and peritumoral vein diameter,as independent risk factors for poor postoperative prognosis in patients with stage I non-small cell lung cancer.