Correlation Of ¹⁸F-FDG PET/CT Metabolic Parameters With CT Enhancement And Clinical Features In Non-small Cell Lung Cancer

Objective:To explore the relationship between ¹⁸F-FDG PET/CT metabolic parameters and CT enhancement in the primary lesions of non-small cell lung cancer（adenocarcinoma,squamous cell carcinoma）,and to provide important information for the evaluation of the efficacy of anti-tumor angiogenesis in patients with non-small cell lung cancer.To explore the relationship between ¹⁸F-FDG PET/CT metabolic parameters of primary non-small cell lung cancer and gender,age,smoking history,pathological type,anatomical type,maximum diameter,TNM stage,and provide reference for the diagnosis and treatment of patients with non-small cell lung cancer.Methods:Retrospective analysis of 42 patients with lung cancer diagnosed by pathology,¹⁸F-FDG PET/CT examination,CT plain scan and enhanced examination and clinical data were performed before the operation,and the PET/CT metabolic parameters of the primary lung cancer lesion were determined:maximum standardization Maximum standardized uptake value（SUV max）,metabolic tumor volume（MTV）and total lesion glycolysis（TLG）.The SPSS 21.0 statistical software was used for statistical processing of the above data.The comparison between the ¹⁸F-FDG PET/CT metabolic parameters of lung cancer and the CT enhancement degree of the solid component of the primary lesion was performed by one-way analysis of variance.The comparisons between PET/CT metabolic parameters and gender,age,smoking history,pathological type,anatomical type,maximum diameter,and TNM staging were all performed by independent sample t test.The correlation between PET/CT metabolic parameters and CT enhancement peaks in different periods was analyzed by Pearson correlation.The correlation between PET/CT metabolic parameters and gender,age,smoking history,pathological type,and TNM staging were all analyzed by Spearman correlation.The test level ofα=0.05.Results:1.There is no correlation between the SUVmax,MTV,TLG of patients with non-small cell lung cancer and the different enhancement degree of CT and the peak of CT enhancement（P>0.05）.2.The three metabolic parameters of patients with non-small cell lung cancer with a maximum diameter of≥3cm are higher than those with a maximum diameter of<3cm.The SUVmax and TLG of the male group are higher than those of the female group,and the SUVmax of the smoking history group is higher than that of the non-smoking group,squamous cell carcinoma The TLG of the group was higher than that of the adenocarcinoma group,and the difference was statistically significant（P<0.05）.3.The MTV of lung cancer in the III+IV group was higher than that in the I+II group,and the MTV and TLG of the T3+4 group were higher than those of the T1+2group.The differences were statistically significant（P<0.05）.4.There was no statistically significant difference between the three metabolic parameters of patients with different age groups,N staging,M staging,anatomical type and non-small cell lung cancer（P>0.05）.5.The three metabolic parameters of patients with non-small cell lung cancer are moderately correlated with the maximum diameter（P<0.05）.Different T stages are moderately correlated with MTV and TLG,and gender,different N stages and SUVmax are all low.Correlation（P<0.05）.6.There is no correlation between MTV,TLG and gender and N staging in patients with non-small cell lung cancer（P>0.05）.The three metabolic parameters of patients with non-small cell lung cancer have no correlation with age,smoking history,pathological type,clinical stage,and M stage（P>0.05）.Conclusions:1.There are differences between gender,smoking,pathological type,maximum diameter,clinical stage and some metabolic parameters of non-small cell lung cancer PET,while the difference between age,anatomical type and PET metabolic parameters is not obvious.2.There is no correlation between PET metabolic parameters of non-small cell lung cancer and CT enhancement peaks in different periods,suggesting that SUV may not be suitable for the evaluation of the efficacy of NSCLC anti-tumor angiogenesis therapy.3.There is a moderate correlation between the maximum diameter and PET metabolic parameters of non-small cell lung cancer;gender,N staging,T staging and some metabolic parameters of non-small cell lung cancer PET have low to moderate correlations.