| Objective:The association between N/OFQ levels and β1-AAbs was evaluated by measuring serum levels of endogenous norkephin(N/OFQ),interleukin-6(IL-6),and β1-AAbs in patients with chronic ischemic heart failure.Methods:A total of 216 patients with chronic ischemic heart failure were enrolled and classified into grades Ⅱ ～ Ⅳ according to clinical symptoms,auxiliary examination indexes and cardiac function grading standard of New College of Cardiology(NYHA).Plasmaβ1-AAbs,N/OFQ,and IL-6 were measured on an empty stomach.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),and left ventricular end-systolic diameter(LVESD)were measured by echocardiogra-phy.According to the results of β1-AA detection,40 patients in β1-AAbs(+)group and 176 patients in β1-Aabs(-)group were divided into two groups,and the relevant indexes of the two groups were analyzed.Results:Compared with negative patients,β1AAbs positive patients had higher plasma levels of N/OFQ and IL-6,faster average heart rate,more occurrence times of ventricular arrhythmias,higher incidence of multigenic ventricular arrhythmias,higher NTpro-BNP level,lower ejection fraction(LVEF),and larger left ventricular end-systolic diameter(LVESD)(p < 0.05).There were no differences in non-ventricular arrhythmia and left ventricular end-diastolic diameter(LVEDD)between 2 groups(P > 0.05).The results of positive ROC diagnostic model of β1-AAbs showed that the AUC of β1-AAbs positive in serum of patients with chronic ischemic heart failure predicted by N/OFQ and IL-6analysis were 0.8192 and 0.6706,respectively.Conclusion:N/OFQ may be correlated with β1-AAbs positivity in serum of patients with chronic ischemic heart failure,and N/OFQ may be involved in multiple links of the pathogenesis of β1-AAbs,and in the range of chronic ischemic heart failure,N/OFQ detection in patients with β1-AAbs positivity has certain predictive value. |
PDF Full Text Request