| Objective:To observe the serum concentration of nociceptin/orphanin FQ（N/OFQ）in patients with diabetes during perioperative period,and to explore the relationship between N/OFQ and sympathetic nervous system and myocardial injury.Methods:Sixty-six,American Society of Anesthesiologists physical statusⅠorⅡpatients,aged 60-69 years,with elective unilateral knee replacement under subarachnoid space in the Second Hospital of Shanxi Medical University from May to August 2019 were selected and divided into diabetic group（group D,n=33）and non-diabetic group（group N,n=33）.The 30 min before anesthesia（T0）,1 h after operation（T1）and 24 h after operation（T2）Blood glucose,serum N/OFQ,norepinephrine（NE）were measured at 30 min before anesthesia（T0）,1 h after operation（T1）and 24 h after operation（T2）,serum cardiac troponinⅠ（cTnⅠ）concentration were measured at T0and T2.Results:The levels of blood glucose,serum N/OFQ and c TnⅠconcentration in group D were significantly higher than those in group N,and the concentration of NE was lower than that in group N at T0（P<0.05）.The levels of blood glucose,serum N/OFQ,NE concentration in group D at T1 were higher than those at T0（P<0.05）.The blood glucose in group N at T1 was higher than that at T0（P<0.05）,there was no significant difference of serum N/OFQ,NE from T0 to T1（P>0.05）.The serum c TnⅠconcentration at T2 in two groups was higher than that at T0,and the increase in group D was greater（P<0.05）.The serum N/OFQ of group D from T0to T1 was positively correlated with the change trend of blood glucose and NE（P<0.05）.The serum c TnⅠof group D from T0to T2 was positively correlated with the change trend of N/OFQ,blood glucose and NE from T0 to T1（P<0.05）.Conclusion:The preoperative serum N/OFQ concentration in diabetic patients undergoing unilateral knee replacement surgery was increased,and the increase in N/OFQ concentration during the operation was related to the increase in NE concentration,and these changes were related to the damage of myocardial cell during the operation. |
