Efficacy Of Bihemisphere Non-invasive Brain Stimulation On Motor Aphasia After Stroke:A Meta-analysis

Objective:Meta-analysis was used to explore the efficacy of bihemisphere non-invasive brain stimulation(NIBS)on motor aphasia after stroke,and provide more theoretical basis for clinicians to use bilateral hemisphere NIBS in the treatment of motor aphasia after stroke.Methods:Search Chinese and English databases such as Pub Med,Web Of Science,The Cochrane Library,Embase,CNKI,Wanfang,Weibo,and Yizhi.com from the establishment of the database to January 2023.Search for relevant research literature on the treatment of motor aphasia after stroke by bilateral transcranial direct current stimulation(t DCS)and repetitive transcranial magnetic stimulation(r TMS),After evaluating the quality of the included literature,the outcome indicators were: Aachen Aphasia Test(ANT),Boston Naming Test(BNT),Psycholinguistic Assessment Training System of Chinese Aphasia(PACA),standardized language test The Hemispheric Stroke Scale(HSS)language component and the Western Aphasia Battery(WAB)extracted naming,repetition,and understanding components,and used Rev Man5.4 software for meta analysis of the data.Results:There are a total of 9 articles and 287 cases that meet the inclusion criteria.Among them,there is a statistically significant difference in the naming ability score(SMD=0.94,95% CI: 0.41 ～ 1.47,P=0.0005)of bilateral NIBS on post stroke motor aphasia.After subgroup analysis,the overall effect of bilateral t DCS and r TMS stimulation on post stroke motor aphasia is better than the control group,and there is no statistical difference between different intervention methods(two different subgroups).However,there was no significant difference in the scores of motor aphasia repetition ability(SMD=0.97,95% CI:-0.04～1.98,P=0.06)and comprehension ability(SMD=0.37,95% CI:-0.67～1.41,P=0.49)between the two hemispheric NIBS groups after stroke.Conclusion:The treatment of motor aphasia after stroke by bi hemispheric non invasive brain stimulation has a positive effect,especially on naming ability.The therapeutic effect on understanding and retelling ability needs further research,and there is no significant difference between transcranial direct current stimulation and repetitive transcranial magnetic stimulation in terms of naming ability.