Analysis Of Important Influencing Factors Of Anxiety And Depression In Patients Undergoing Assisted Reproductive Therapy

Objective:To investigate the status of anxiety and depression in infertile women undergoing assisted reproductive therapy(ART),analyze the influencing factors of anxiety and depression,and explore the relationship between anxiety and depression and reproductive stress.Methods:A case-control study was conducted.The study group selected 260 infertile women who were treated with assisted reproductive therapy in the outpatient department of reproductive department of Luohe City Hospital from July 2022 to December 2022,and the control group selected 220 married women of childbearing age who were examined in the physical examination department of Luohe Central Hospital during the same period.The control group filled in the personal information form,anxiety scale(SAS)and depression scale(SDS);Self-designed questionnaire,SAS,SDS,and Fertility Problem Inventory(FPI)were completed in the study group.The observation index includes: age,educational background,residence,occupation type,family average monthly income,family structure type;Infertility years,infertility types,children,main sources of fertility pressure,indications for assisted reproductive treatment,time of assisted reproductive treatment,number of transplants,and previous treatment costs;SAS、SDS、FPI。To compare the detection rate and score difference of SAS and SDS between the study group and the control group,to understand the status of anxiety and depression of infertile women with assisted reproductive therapy,to analyze the influencing factors of anxiety and depression,and to explore the correlation between SAS,SDS and FPI of infertile women with assisted reproductive therapy.Results:1.220 subjects in the control group were given questionnaires,212 subjects were effective,the completion rate was 96.4%.The study group distributed questionnaires to 260 people,246 of them were effective,the completion rate was 94.6%.There were no significant differences in age,education,residence,occupation,family income and family structure between the two groups(P>0.05).2.The prevalence of anxiety in the control group was 7.55%,while that in the study group was37.40%.The anxiety score of the control group was 36.77 ± 8.44,and that of the study group was 46.31 ±10.75.The anxiety detection rate and anxiety score of the study group were significantly higher than those of the control group(P<0.05).The prevalence of depression in the control group was 10.38%,and that in the study group was 30.08%.The depression score of the control group was 42.02 ± 8.06,and that of the study group was 47.87 ± 10.21.The detection rate and depression score of the study group were significantly higher than those of the control group(P<0.05).3.In the study group,64 persons(26.02%)were detected with mild anxiety,27 persons(11.0%)with moderate anxiety and 1 person(0.4%)with severe anxiety;There were 52 patients with mild depression,accounting for 21.14%,19 patients with moderate depression,accounting for 7.72%,and 3patients with severe depression,accounting for 1.22%.4.The results of multivariate logistic regression analysis showed that free/unemployed,infertility years>5 years,reproductive pressure mainly coming from loved ones,and transplant frequency>5 were risk factors for anxiety;A moderate monthly income per capita(3000 to 5000)is a protective factor for anxiety.Age>40 years old,educational background of college or above,sources of reproductive pressure from parents or public opinion,and duration of assisted reproductive therapy>3 years are the influencing factors for depression.The difference was statistically significant(P<0.05).5.In the study group,the anxiety or depression patients had higher fertility stress scores than the asymptomatic group,and the difference was statistically significant(P<0.05).Social stress,marital relationship,parental role demands and FPI total score were positively correlated with depression(P<0.05).Anxiety was positively correlated with marital relationship,childless stress and total score of FPI(P<0.05).Conclusion:Assisted reproduction treatment of infertility patients with obvious anxiety depression.Age,educational background,occupational type,duration of infertility,main sources of reproductive pressure,duration of assisted reproductive therapy,and number of transplants are the influencing factors for anxiety or depression.The average monthly income per capita in a family is a protective factor for anxiety.Meanwhile,anxiety and depression are positively correlated with reproductive related stress.