| Objective:This paper discusses the clinical efficacy of Professor Xue Hanrong’s method of regulating qi,eliminating phlegm and removing blood stasis in the treatment of pulmonary nodules with qi stagnation and phlegm stasis.By observing the changes of nodule diameter and TCM syndrome score in patients with pulmonary nodules,the clinical efficacy and safety of regulating qi,eliminating phlegm and removing blood stasis in the treatment of pulmonary nodules are objectively evaluated,so as to provide ideas for the prevention and treatment of pulmonary nodules with traditional Chinese medicine.Method:A total of 66 cases meeting the inclusion criteria were selected and divided into the experimental group and the control group with 33 cases respectively according to the random number table.In addition to imaging follow-up,the experimental group was also treated with regulating qi and removing phlegm and removing stasis formula,while the control group was only treated with imaging follow-up.The observation period was 12 weeks.The maximum diameter change of pulmonary nodules,nodule number,nodule location,nodule density,primary and secondary diseases of traditional Chinese medicine,TCM syndrome scores and safety indexes of patients in the two groups were recorded respectively before and after treatment.The collected data were sorted out and SPSS 27.0 software was used for relevant statistical analysis.Result:After strictly following the criteria of dropping out,eliminating and terminating the trial,a total of 63 cases were included in the clinical study.Two cases in the trial group fell out because of long-term business trip and could not cooperate with the clinical study,while one case in the control group could not cooperate with the clinical study because of family accident.The results are as follows:1.In terms of gender distribution,there were 18 male patients and45 female patients,with a male-female ratio of 1:2.5;In terms of age distribution,patients mainly concentrated in 36-59 years old,accounting for 63.49% of the total number of patients.In the distribution of smoking or second-hand smoke history,39 people had smoking or second-hand smoke history,24 people denied smoking or second-hand smoke history.2.Analysis of the number,location and density of pulmonary nodules:in the distribution of the number of pulmonary nodules,there are more patients with multiple pulmonary nodules,and the ratio of multiple pulmonary nodules to solitary pulmonary nodules is about 2.84:1;In the distribution of pulmonary nodules,the right lung is more than the left lung,and the right upper lobe is the most in the right lung,accounting for 46.34% of the right lung;In the density distribution of pulmonary nodules,patients with ground-glass nodules were more than those with solid nodules,accounting for 63.33% of the total number.3.Analysis of changes in the maximum diameter of pulmonary nodules:the average maximum diameter of pulmonary nodules in the experimental group was 6.375 ± 1.897 mm before treatment,5.065 ± 1.861 mm after treatment,and the maximum diameter of pulmonary nodules decreased significantly after treatment(P<0.05);The average maximum diameter of pulmonary nodules in the control group was 6.375 ± 1.897 mm before treatment and 6.250 ± 2.140 mm after treatment.There was no significant change in the maximum diameter of pulmonary nodules after treatment(P>0.05).It shows that the test group is superior to the control group in the extent of the maximum diameter reduction of pulmonary nodules.4.Analysis of efficacy related to lung nodule diameter: The total effective rate of the experimental group and the control group was about38.71% and 9.38%,respectively,P<0.05,indicating that the treatment plan of the experimental group was better than the control group in terms of efficacy related to lung nodule diameter.5.Improvement of main and secondary symptoms of traditional Chinese medicine: after treatment,the experimental group can significantly improve the clinical symptoms of "expectoration","chest tightness","irritability/depression","foreign body sensation in the throat","cough","fatigue and fatigue","head and body fatigue","bitter mouth","poor appetite/poor appetite"(P<0.05);The main and secondary symptoms in the control group did not change significantly(P>0.05).In terms of the improvement of primary and secondary symptoms of traditional Chinese medicine,the efficacy of the experimental group was better than that of the control group.6.Analysis of changes in TCM syndrome score: TCM syndrome score of experimental group decreased significantly before and after treatment(P< 0.001),while that of control group decreased somewhat before and after treatment(P < 0.05).Comparison between groups after treatment,P < 0.001,indicating that the reduction degree of TCM syndrome score in the experimental group was significantly better than that in the control group after treatment by regulating qi and removing phlegm and removing blood stasis.7.Analysis of curative effect of TCM syndrome: the total effective rate of the test group and the control group was 90.32% and 18.75%,P<0.001,indicating that the treatment plan of the test group had more advantages in clinical efficacy.8.Analysis of safety indicators: 63 patients did not have obvious adverse reactions during the study,indicating that the prescription for regulating qi,removing phlegm and removing blood stasis is safe in clinical application.Conclusion:1.Regulating qi,eliminating phlegm and removing blood stasis can reduce the nodule diameter in patients with pulmonary nodules of qi stagnation and phlegm stasis type.2.Regulating qi,dispelling phlegm and removing blood stasis can reduce the TCM syndrome score of patients with pulmonary nodules of qi stagnation and phlegm stasis type,and can significantly improve the clinical symptoms.3.Regulating qi,eliminating phlegm and removing blood stasis in the treatment of pulmonary nodules with qi stagnation and phlegm stasis has good clinical effect.4.Regulating qi,eliminating phlegm and removing blood stasis in the treatment of pulmonary nodules with qi stagnation and phlegm stasis has no serious adverse reactions and high safety. |
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