Application Of I-PRF Combined With Thermo-Sensitive Type Hydroxybutyl Chitosan In Wound Repair

Objective:This study explores the clinical efficacy and significance of the combination of injectable platelet rich fibrin(i-PRF)and thermo-sensitive type hydroxybutyl chitosan(HBC)in wound repair.Methods: According to the inclusion and exclusion criteria,40 patients who visited our hospital from July 2021 to December 2022 were selected as the study subjects.The experimental group and control group each had 20 people,and the experimental group was treated with i-PRF combined with thermo-sensitive type HBC regimen;The control group was treated with temperature sensitive HBC hydrogel.Compare the preparation of the wound bed,granulation tissue growth,and patient pain between the two groups before and on the 7th and14 th day after treatment,and compare the wound healing efficacy,patient satisfaction,and incidence of complications between the two groups after one month of treatmentResults:(1)Patient Wound Bed(WBS)Score: Before treatment,there was no statistically significant difference in WBS scores between the two groups(P>0.05).After treatment,the experimental group had a better overall wound healing,a higher WBS score,and a statistically significant difference between the groups(P<0.05).(2)Patient wound granulation tissue score: Before treatment,there was no statistically significant difference in granulation tissue score between the two groups(P>0.05).After treatment,the granulation tissue in the experimental group grew earlier and had a higher coverage rate,with statistical significance(P<0.05).(3)Patient’s wound pain score: Before treatment,there was no statistically significant difference in pain scores between the two groups(P>0.05).After treatment,both groups showed a downward trend in pain scores,but the experimental group showed a more significant downward trend in pain scores,with statistical significance(P<0.05).(4)Patient wound healing efficacy: The experimental group had a higher wound healing rate and better efficacy,with statistically significant differences between groups(P<0.05).(5)Patient satisfaction survey: The experimental group showed higher satisfaction,with statistically significant differences between groups(P<0.05).(6)Wound complications: the incidence of complications in the experimental group was lower,and there was significant difference between the two groups(P < 0.05).Conclusion: Compared with the application of temperature-sensitive type HBC hydrogel alone,the application of i-PRF combined with temperature-sensitive type HBC in clinical treatment of wounds can significantly improve the efficacy of wound healing,improve the quality of wound healing,reduce patient pain,improve patient satisfaction and reduce the occurrence of complications.i-PRF has fluidity and its residence time in the wound is too short,so it is difficult to establish an effective barrier to complex wounds.The combined application of i-PRF and temperature-sensitive type HBC in wounds can not only solve the problem of serious local drug loss caused by the application of i-PRF alone,but also promote the slow release of growth factors in i-PRF as a drug carrier,and solve the problem of poor timeliness of i-PRF alone.This not only provides a new method for clinical wound treatment,but also provides a theoretical basis for clinical application of i-PRF and temperature-sensitive type HBC.