Observation Of The Clinical Outcomes Of Regenerative Endodontics Procedures Of Immature Permanent Necrotic Teeth Using Injectable-Platelet-Rich Fibrin

Objective: The purpose of this study was to discuss the clinical and radiological outcome of using injectable-platelet-rich fibrin(i-PRF),a second-generation platelet concentrate,in the revascularization procedure of immature teeth with necrotic pulp.Methods: Select 10 immature and 1 mature permanent necrotic teeth from which roots ceased to develop caused by trauma or carious exposure and dental anatomic variations from September 2016 to September 2017.Two clinicians operate REPs followed the guideline of‘‘Considerations for Regenerative Procedures’ ’ which created by the American Association of Endodontists(AAE)Regenerative Endodontics Committee,updated June,2016.The follow-up should consist of clinical and radiographic examinations.All cases were recorded in detail,including resolution of periapical radiolucency,increased thickening of the canal walls,continued root maturation and positive response to pulp test.Results: During the observation period of 6-18 months,11 teeth showed improvement in the healing of periapical lesions,7 teeth showed different degrees of increased thickening of the canal walls,continued root maturation and apical closure.1 tooth elicited a positive response to an electric pulp test.Conclusion: i-PRF acted as the successful scaffolds for the immature tooth with necrotic pulp and is potentially an ideal and efficiency scaffold for regenerative endodontic procedures.