The Study Of Association Between Body Mass Index And Ectopic Pregnancy

Purpose Ectopic pregnancy(EP)is an important cause of death in the first trimester of pregnancy.It is important to understand the risk factors of ectopic pregnancy to reduce the incidence of ectopic pregnancy and avoid maternal death.In 2021 the World Health Organization(WHO)recommended that the boundary of overweight and obesity in adults be redefined,with a body mass index(BMI)in the range of 25-29.9 kg/m~2 being overweight and BMI≥30 kg/m~2 being obese.Studies on the correlation between BMI and disease have received increasing attention;however,few studies have been reported on the correlation between BMI and ectopic pregnancy.Methods We retrospectively studied the EP women as a case group and the deliveries as a control group in the central hospital of Wuhan during 2017～2021.First,the sociodemographic characteristics of the patients were investigated.Next,the distribution of BMI was analyzed,as well as differential analysis of factors associated with BMI and ectopic pregnancy was performed.Finally,univariate and multivariate binary logistic regression analysis was conducted to analyze the association of the variables of age,parity,history of induced abortion,history of ectopic pregnancy History of spontaneous abortion,History of appendectomy surgery and BMI(underweight,BMI<18.5kg/m~2;normal weight,18.5 kg/m~2≤BMI≤24.9kg/m~2;overweight 25kg/m~2≤BMI≤29.9kg/m~2;obese,BMI≥30kg/m~2)with EP.Results A total of 2119 women were included.They were 659 EP and 1460 deliveries.The mean age of EP patients were 31.5±5.6 years old,and the differences in their occupations were statistically significant(P<0.05),272(42.2%)were employees.From 2017 to 2021,the proportion of women with normal weight tended to increase and the proportion of underweight women tended to decrease(P for trend,P<0.05).Univariate binary logistic regression analysis showed that the variables of age,parity,history of induced abortion,history of ectopic pregnancy and BMI were the risk factors of EP(P<0.05).Multivariate analysis showed that the variables of age>35 years old[(OR(Odds Ratio),5.415;95%CI(Confidence Interval),4.006～7.320,P<0.001],history of ectopic pregnancy(OR,3.944;95%CI,2.405～6.467;P<0.001),history of induced abortion(OR,3.365;95%CI,2.724～4.158,P<0.001)and underweight(OR,1.929;95%CI,1.416～2.628,P<0.001])increased the risk of EP.Conclusion The history of ectopic pregnancy,history of induced abortion and age>35 years old were the risk factors with EP.In addition to these traditional factors,we found those women who were underweight may increase the risk to EP.Our study aims to alert women to the risk factors associated with ectopic pregnancy and for women who are underweight,we advise them to maintain a good and healthy body mass index(18.5 kg/m~2≤BMI≤24.9 kg/m~2)to protect fertility.