Study Professor Li Guangying’s Medication Rule For Depression Based On Data Mining Technology

Objective: By using the Ancient and Modern Medical Case Cloud Platform,we analyzed and explored Professor Li Guangying’s experience in the treatment of depression in terms of the identification of evidence and the use of prescriptions and medicines to provide theoretical guidance and reference for clinical treatment of depression.Methods: From December 2021 to October 2022,we collected information on cases of depression treated by Professor Li Guangying using traditional Chinese medicine,standardized the data,and entered them into the "Ancient and Modern Medical Case Cloud Platform".The data mining methods such as mutual information method,rule analysis,and entropy clustering of complex systems were used to analyze the frequency and correlation rules of each drug in the prescriptions of medical cases,and to explore Professor Li Guangying’s experience in treating depression.Results:1.More female than male patients with depression attended Professor Li Guangying’s clinic,with a male to female ratio of about 1:1.96.2.The TCM evidence types of depression patients in this study were liver qi stagnation evidence the most,followed by qi stagnation and fire evidence and heart-kidney yin deficiency evidence.3.The results of frequency statistics showed that 225 prescriptions contained a total of110 herbal medicines with a total frequency of 5357 times,among which the drugs with high application frequency were: asparagus(215),mother-of-pearl(214),Chuanxiong(213),Huanglian(212),cinnamon(212),Pueraria lobata(211),oyster(210),Chaihu(209),heliotrope bark(202),roasted licorice(200),lily of the valley(195),white peony(192),gardenia(186),tempeh(182),aromatic herb(176),heliotrope shell(186),magnetite(163),sour date palm(152),astragalus(149),and Chenpi(142).4.The statistical results of the four qi and five tastes information of the drugs in this study showed that the four qi of the drugs were mainly cold,and the five tastes were mainly sweet and pungent.5.The results of the statistical results of the classification of the drugs used into the meridians showed that the drugs classified into the liver meridian appeared most frequently,with a frequency of 2562 times,followed by the drugs of the heart and lung meridians.6.The statistical results of the efficacy of the drugs used showed that the most frequent occurrence of herbs with the effect of calming liver and yang was 407 times,followed by drugs for de-stressing the liver and calming liver and yang.7.The top 10 drug combinations in order of association rule results were: Huang Lian,Tian Ma;Tian Ma,Mother of Pearl;Mother of Pearl,Chuanxiong;Chuanxiong,Tian Ma;Oyster,Mother of Pearl;Tian Ma,Cinnamomum;Mother of Pearl,Cinnamomum;Pueraria Mirifica,Tian Ma;Pueraria Mirifica,Cinnamomum;Chuanxiong,Chai Hu.8.The results of the drug-evidence correlation showed that Professor Li Guangying’s common prescription for the treatment of liver depression and qi stagnation was the formula of adding and subtracting Chai Hu and sparing the liver;for the treatment of qi depression and fire was the formula of adding and subtracting Gentian and liver diarrhea soup,and for the treatment of heart and kidney yin deficiency was the formula of adding and subtracting Liu Wei Di Huang Wan.9.The clustering analysis of the drugs used yielded five categories of drug combinations:(i)lily,peony,and tempeh;(ii)calamus,astragalus,Chenpi,aromatic herb,and heliotrope;(iii)cypress seed,sour date palm,and semen;(iv)heliotrope bark,mother-of-pearl,Chuanxiong,and Chaihu;and(v)oyster,asparagus,Huanglian,Pueraria lobata,and cinnamon.10.The screening of this study revealed that the four commonly used core formulas of Prof.Li Guangying were Chai Hu Dredging Liver San(Chai Hu,Xiang Xiang Xiang,Citrus Aurantium,Chuan Xiong,Roasted Licorice,Bai Shao,Chen Pi),Sheng Yang Yi Stomach Tang(Huang Qi,Roasted Licorice,Bai Shao,Huang Lian,Chai Hu),Sheng Ma Ge Gen Tang(Bai Shao,Roasted Licorice,Ge Ge Gen),Ge Gen Huang Lian Huang Scutellaria Tang(Ge Gen,Roasted Licorice,Huang Lian),and Hepatization Decoction(Chen Pi,Bai Shao,Gardenia).Conclusion: Professor Li Guangying is good at using ancient prescriptions in clinical treatment of depression,absorbing the essence of them and integrating the strengths of various schools of thought,without being confined to one pattern.In addition to treating the symptoms,he often uses a combination of medicines to improve and consolidate the therapeutic effect.He is good at using medicine pairs,often combining dynamic and static drugs,combining hot and cold,complementing and diarrhea,lifting and lowering,etc.,and applying them according to the physiological and pathological characteristics of the internal organs.