Analysis Of Risk Factors For Helicobacter Pylori Infection And Benign Gallbladder Disease

Objective: A retrospective study was used to analyze the risk factors of H.pylori infection and benign gallbladder disease,the correlation between H.pylori infection and benign gallbladder disease and the differences in the prevalence of benign gallbladder disease in various H.pylori infection states.Methods:For this study,we selected 155 patients who were admitted to the Department of Gastroenterology and Department of Hepatobiliary Surgery of the First People’s Hospital of Yunnan Province Hospital between April 2021 and April 2022.We excluded patients who had comorbid atrophic gastritis,peptic ulcer,or gastric cancer based on their gastroscopic findings.We then collected clinical data from eligible patients.The subject paper outlines a comprehensive list of medical tests that are conducted on patients.These tests cover various aspects such as gender,age,height,weight,body mass index,blood routine,lipid level,liver and kidney function,¹⁴C breath test,abdominal ultrasound,H.pylori antibody typing,and gastrin level.The participants were split into two groups: those who tested positive for Hp and those who tested negative,based on the ¹⁴C breath test.Additionally,they were divided into two groups based on the presence or absence of gallbladder disease,as determined by abdominal ultrasound results.The objective of this study was to examine the risk factors linked to H.pylori infection and gallbladder disease.The dependent variables were the presence of Hp infection and gallbladder disease,respectively.The study aimed to determine the correlation between the occurrence of gallbladder disease and Hp infection.To compare the incidence of gallbladder disease in three groups,we combined the results of the ¹⁴C breath test and H.pylori antibody typing into previously infected,currently infected,and uninfected groups.The patients were categorized into four groups based on their conditions: those with both gallbladder disease and Hp infection,those with Hp infection but without gallbladder disease,those with gallbladder disease but without Hp infection,and those without either condition.This categorization was determined by combining the results of a¹⁴C breath test and abdominal ultrasound.The gastrin levels of each group were then compared.Statistical analysis was performed using SPSS25.0.Results:（1）In the group with gallbladder disease compared with the group without gallbladder disease,there were differences in body mass index,body weight,Hp infection rate,white blood cells,liver function,serum albumin,lipid levels,and gastrin levels between the two groups（P< 0.05）,and logistic regression analysis concluded that Hp infection,elevated white blood cell count,elevated triglycerides,and elevated gastrin may be risk factors for the development of gallbladder disease.In the Hp-positive and Hp-negative groups,there were differences in the levels of leukocytes,liver function,lipids,fasting glucose,and gastrin between the two groups（P < 0.05）.（2）The incidence of gallbladder disease was different between the Hp-negative group and the Hp-positive group（x²=14.24,P<0.01）;the difference in the incidence of gallbladder disease was statistically significant in the presently infected group compared with the previously infected and uninfected groups（x²=6.514,P<0.016）.（3）There was a difference in gastrin levels between patients with both gallbladder disease and Hp infection and patients without gallbladder disease and Hp infection（Z=15.069,P<0.05）.Conclusions:Hp infection and elevated gastrin may be risk factors for the development of benign gallbladder disease,and there is a correlation between benign gallbladder disease and Hp infection.the incidence of benign gallbladder disease is higher in patients with current Hp infection than in the previously infected and uninfected groups.Gastrin levels were significantly higher in patients with benign gallbladder disease combined with Hp infection.