A Cross-sectional Study Of The Association Between Dietary And Lifestyle Inflammation Scores With Hyperuricemia

Objective: Previous studies have shown that Dietary and Lifestyle Inflammation Scores(DLIS)is related to a variety of chronic diseases(such as metabolic syndrome,diabetes,etc.).DLIS is further divided into Dietary Inflammation Score(DIS),which includes dietary components,and Lifestyle Inflammation Score(LIS),which includes lifestyle components.However,at present,the association between DLIS and chronic diseases needs to be further confirmed,and there is still a lack of research on the association between DLIS and Hyperuricemia(HUA)in China.Therefore,this study is based on "Hanman Community Cohort" under the subproject "Regional Ethnic Cohort" of "Northeast Regional Natural Population Cohort".which was used for exploring associations with HUA based on DLIS in this population so that afford epidemiological evidence for further prevention and control of HUA.Methods: Based on inclusion and exclusion criteria,9802 people were included in the study,which used a cross-sectional approach to explore the relation between DLIS and HUA.Dietary information was collected using a semi-quantitative food frequency questionnaire.General demographic characteristics,dietary history,personal lifestyle habits,physical activity level,disease history,physical examination indicators,blood test results and other information of the subjects were collected through face-to-face questionnaires,physical examination and hematological indicators.According to uric acid level,they were divided into HUA group and non-HUA group,and the scores of DLIS,DIS and LIS were divided into tripartite group.Analysis of variance and rank sum test were used to compare different dietary intake.Logistic regression analysis was used to explore the correlation between DLIS,DIS,LIS,and HUA.Subgroup analysis and multiplicative interactions were performed according to age,sex,ethnicity and chronic disease status of the subjects.In addition,a sensitivity analysis was performed to explore the association between DLIS,DIS,LIS with HUA,according to the international standard for the definition of HUA: serum uric acid concentrations higher than 420μmol/L,regardless of gender.Results: Among the 9802 research objects,there were 1780 HUA patients,with a prevalence of 18.16%.The prevalence was 27.55% in males and 13.80% in females.The results of regression analysis showed that DLIS and DIS were statistically significant in the unadjusted confounder model,but not in the final adjusted confounder model,and LIS were statistically significant in HUA regardless of whether the confounder model was adjusted.In the final adjusted confounder model,compared with the lowest group,the odds ratio(OR)and 95% confidence interval(CI)for the LIS in the highest group were 2.98(2.57,3.46),the trend P value < 0.05.After sample stratification,the results showed that in age,sex,ethnicity and chronic diseases,there was no interaction with DLIS and DIS,but in LIS,indicating that LIS was associated with the risk of HUA,and LIS was associated with an increased risk of HUA at age stratification.The corresponding OR(95%CI)were 3.32(2.30,4.82),3.39(3.32,5.26),2.64(2.08,3.37),and 2.96(2.30,3.84)for age ≤39,40-49,50-59,and ≥60 years,respectively.For age ≤39,40-49,50-59 and ≥60 years,respectively.In the stratification of male,female,Han,other ethnic groups,with chronic disease and without chronic disease,the LIS was associated with the increased risk of HUA,and the corresponding OR(95%CI)were 2.23(1.71,2.92),3.27(2.73,3.92),2.97(2.53,3.50),3.04(2.08,4.51),2.90(2.47,3.40),and3.33(2.23,5.00).According to the international standard for the diagnosis of HUA,sensitivity analysis was conducted,and the results showed that the sensitivity analysis was consistent with the main analysis,and LIS was statistically significant with the risk of HUA,and higher LIS was significantly associated with the increased risk of HUA.Conclusion: The results demonstrated that no significant relation was found between DLIS and DIS with the risk of HUA.A significant association was found between LIS and the risk of HUA.The higher LIS,the higher the risk of HUA.