Clinical Significance Of Serum NLR,PLR,and RDW In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective: This article investigated the expression of NLR(lymphocyte-toneutrophil ratio),PLR(lymphocyte-to-platelet ratio)and RDW(red blood cell distribution width)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and the practical application of these indices in assessing disease severity and diagnosing AECOPD.Methods: From January to December 2022,50 patients diagnosed with AECOPD were selected in the respiratory department of the Fifth Affiliated Hospital of Xinjiang Medical University,and 50 patients were confirmed as stable patients with COPD,and 100 cases were selected as the subjects of this study.In addition,50 healthy people who had undergone physical examinations in our hospital between January 2022 and December 2022 were also selected as the control group for this study.Among them,the AECOPD group was divided into four groups according to the severity of the disease:1,2,3,and 4.The basic data of each group,such as sex,age,smoking history and BMI,were collected,and the fasting venous blood of each group was collected,and the levels of NLR,PLR and RDW were measured,so as to evaluate the value of NLR,PLR,and RDW in diagnosing AECOPD disease.Results:1)General data comparison.There were no significant differences between groups in smoking history,BMI,age,sex and other factors(P>0.05),indicating that the general data were balanced and comparable.2)Comparison between different patient measures in the AECOPD group.Comparison of NLR,PLR,and RDW in the AECOPD group.NLR,PLR,and RDW levels were statistically significant,and NLR levels were higher in GOLD grade 4 than in GOLD grade 1 and GOLD grade 2(P<0.05);3)were compared between the three groups.The NLR,PLR,and RDW of the AECOPD group were higher than those in the healthy control group and the stable group,and the differences between the groups were statistically significant(P<0.05).4)The diagnostic value of NLR,PLR and RDW for AECOPD.The AUC(95% CI)of AECOPD diagnosed with NLR,PLR and RDW was 0.969(0.913-0.993),with a sensitivity of80.00% and specificity of 98.00%.The sensitivity and specificity of AECOPD was84.00% and 98.00% when the clinical cut-off value of NLR was 3.08,and the sensitivity and specificity of AECOPD were 90.00% and 68.00% when the clinical cut-off value of PLR was 126.39.The sensitivity and specificity of AECOPD were 68.00% and 90.00%when the RDW clinical cut-off value was 13.30.The combined diagnosis of AECOPD by NLR,PLR,and RDW has a high value.Conclusions:1)NLR,PLR,RDW levels are elevated in AECOPD,which can diagnose AECOPD and it also helps to assess the severity of AECOPD patients.It can provide an objective basis for patients to choose appropriate clinical management.2)The test values of clinical test indicators in stable COPD patients were also higher than those of healthy people,indicating that stable COPD patients were still in a chronic inflammatory state,and NLR,PLR and RDW may be related to chronic inflammation.3)NLR,PLR and RDW help the diagnosis of AECOPD,and the combined diagnosis of AECOPD by NLR,PLR and RDW indicators can improve the specificity of disease diagnosis.