Clinical Characteristics And Prognosis Analysis Of 166 Patients With Hodgkin’s Lymphoma

Purpose:To explore clinical characteristics and prognostic analysis of patients with Hodgkin’s lymphoma（HL）.Methods:The clinical data,general characteristics,laboratory tests,clinical manifestations and short-term effects of 166 patients with HL who were diagnosed and treated in our hospital on January 1,2010 and December 31,2019 were collected;The correlation between the above factors and prognosis was analyzed by Log-rank test and Cox proportional risk model;All data were analyzed using SPSS 26.0software.Results:166 patients were between 4 and 77 years old,with a median age of 33years;There were 99 male patients,accounting for 59.6%,and 67 female patients,accounting for 40.4%;The ratio of men and women is 1.47:1.In Ann Arbor stage,there were 5 patients with stage I,accounting for 3.0%,86 patients with stage II,accounting for51.8%while 44 patients（26.5%）with stage III and 31 patients（18.7%）with stage IV.Among the pathological types,153 cases（92.2%）were classic Hodgkin’s lymphoma（CHL）,and 7 cases（4.2%）were nodular lymphocytic lymphoma（NLPHL）;6 cases（3.6%）were not differentiated by pathology.The median follow-up time was 69.5 months（2-151months）.There were 20 cases with incomplete data and lost follow-up.The lost follow-up rate was 12.1%（all lost follow-up data were used as censored data）.After the initial treatment,166 patients with HL were evaluated by color Doppler ultrasound,CT or PET/CT.After the treatment,109 patients（65.7%）reached CR or CRu,40 patients（24.1%）reached PR,and 17 patients（10.2%）reached SD or PD.During the follow-up,16patients died,including 13 patients died of disease recurrence and progression,and 3patients died of respiratory failure and multiple organ failure.The 3-year cumulative survival rate of patients was 90.7%,and the 3-year cumulative progression-free survival rate was 84.6%.Univariate survival analysis showed:age,presence or absence of B symptoms,Ann Arbor stage,lactate dehydrogenase level,large mass,extranodal involvement,bone marrow involvement,ESR,β₂-MG,albumin,D-dimer,white blood cell count,hemoglobin level and lymphocyte count（all P<0.05）may be the poor prognostic factors of HL patients.Multivariate analysis showed that age≥45 years old,B symptoms,and Ann Arbor stage were independent factors affecting prognosis.Conclusion:Hodgkin’s lymphoma is a hematological malignancy with high cure rate and good prognosis.The pathological types are mainly NSHL and MCHL subtypes.Age≥45 years old,B symptoms,and Ann Arbor stage are independent factors that can potentially affect the prognosis.