The Value Of Preoperative C-Reactive Protein Combined With Fibrinogen To Prealbumin Ratio Scoring System In The Prognosis Of Patients With Hepatocellular Carcinoma

Objective to investigate the Ratio of C-reactive protein(CRP)combined with Fibrinogen to pre-Albumin(FIB).To investigate the prognostic value of FPR scoring system in patients with Hepatocellular carcinoma(HCC).Methods The clinical data of 185 patients with HCC who underwent curative hepatectomy at the Department of Hepatobiliary Surgery,the First Affiliated Hospital of Bengbu Medical College from April 2014 to May 2016 were retrospectively analyzed.Including smoking,drinking,age,sex,hepatitis B,Child-Pugh classification,tumor diameter,tumor number,TNM stage and serum C-reactive protein,fibrinogen,prealbumin,FPR.The optimal cut-off points of FIB,CRP,FPR and PLT were analyzed by Receiver operating characteristic curve(ROC).According to the score of CRP-FPR(C-FPR)group,the patients were divided into three groups: C-FPR 0,C-FPR 1 and C-FPR 2.Univariate and multivariate regression analyses were performed using the Cox proportional hazards model.Kaplan-Meier survival curves with log-rank test were used to evaluate the difference in survival rates between groups.In terms of P<A difference of 0.05 was considered statistically significant.Results The optimal cut-off points of FIB,CRP,FPR and PLT determined by ROC were 4.65g/L,6.51mg/L,16.65 and 167×109/L,respectively.The AUC was 0.654,0.641,0.734 and 0.639,respectively.Age,Child-Pugh classification,viral hepatitis B and tumor number were associated with C-FPR score(P<0.05).Univariate COX regression analysis showed that AFP,TNM stage,tumor diameter,tumor number,CRP,Fib,PLT,FPR,C-FPR were independent risk factors for the prognosis of HCC patients(P< 0.05).Multivariate COX regression analysis showed that TNM stage,tumor diameter,PLT,CRP,Fib,FPR and C-FPR were independent risk factors for the prognosis of HCC patients(P<0.05).Conclusion C-FPR was an independent risk factor affecting the prognosis of patients with HCC after surgery.A higher C-FPR score indicated a poor prognosis of patients with HCC.