Application Value Of Alpha-fetoprotein Combined With Fibrinogen To Albumin Ratio Scoring System In The Prognosis Of Hepatocellular Carcinoma

Objective to investigate the application value of alpha-fetoprotein(AFP)combined with fibrinogen(Fib)and albumin ratio(FAR)scoring system in the prognosis assessment of patients with hepatocellular carcinoma(HCC).Methods The clinical data of 157 patients with hepatocellular carcinoma who underwent radical hepatectomy during the first affiliated hospital of Bengbu Medical College from June 2013 to May 2014 were analyzed retrospectively including age,gender,smoking,alcohol consumption,hepatitis B virus,Child-Pugh classification,tumor site,tumor size,TNM stage,AFP,Fib,platelet(PLT),FAR,The optimal cut-off points for Fib,PLT,FAR were determined by receiver operating characteristic curve(ROC)analysis.According to the A-FAR(AFP and FAR)group score,it is divided into 3 groups: A-FAR 0 points,A-FAR 1 point,A-FAR 2 points.Chi-square test was used to analyze its relationship with clinicopathological factors.Kaplan-Meier method was used for survival analysis.Log-rank method was used for difference test.Univariate and multivariate regression analysis used Cox proportional hazard model.Results According to the ROC curve,the optimal cut-off values for Fib,PLT and FAR are 5.75g/L,157×10^9/L and 0.07,respectively.Age,hepatitis B virus,tumor diameter,and Child-Pugh classification were related to preoperative A-FAR score(P<0.05).Univariate analysis showed that: tumor site,tumor diameter,TNM stage,AFP,Fib,PLT,FAR,A-FAR were associated with prognosis(P<0.05).Multivariate analysis further showed that tumor site,tumor diameter,PLT,FAR and A-FAR are independent risk factors for the prognosis of radical hepatectomy for hepatocellular carcinoma(P<0.05).Conclusion A-FAR is an independent risk factor that affects the postoperative prognosis of patients with hepatocellular carcinoma.A higher A-FAR score indicates a poorer prognosis for patients with hepatocellular carcinoma.